Animals ethics in HKUMed is advised by the Committee on the Use of Live Animals in Teaching and Research (CULATR):
For enquiries, please contact:
Important Notices
- (31 Mar 2022) New Online Submission System for CULATR – CARES
- (May 2022) Emergency and Disaster Management Plan Centre for Comparative Medicine Research
- (07 Mar 2019) Extension of Validity Period of CULATR Approval
- (06 Aug 2013) Disaster Plan for Departmental Animal Facilities and Research Laboratories (obsolete as from Jun 2020)
- (25 Jul 2013) Intra-operative Monitoring (IOM)
- (13 Apr 2012) Revised CULATR Application Form
- (01 Feb 2011) Reminder: Proper Record of Drug Issuance and Usage
- (19 Nov 2010) Reminder: Keeping CULATR-approved Protocol Documents in Animal Rooms and Laboratories
- (17 Nov 2010) Reminder: Monitoring of Animal Usage of PI (Principal Investigator)-Owned Colonies Form
- (04 Mar 2009) Satellite Animal Holding Rooms Occupancy Rate Record
- (18 Dec 2008) Revised CULATR Application Form, Documents & Practices
- (11 Feb 2008) Student Bloc License Guidelines
- (08 Jun 2007) Revised CULATR Documents
- (27 Mar 2007) 3Rs Principles for the Use of Live Animals for Teaching
- (13 Nov 2006) Transport of Living Animals for Research/Teaching Use in the Faculty of Medicine Building (FMB)
- (25 Jul 2006) Animal Quota Reminder for PI-owned Colonies
CULATR Policies and Protocols
- Euthanasia Guidelines (M.79/1222)
- Policy for the Use of Experimental Animals (M.50/1122)
- Policy for the Social Housing of Rabbits (M.49/1122)
- Mouse & Rat Breeding Policy and Related Non-Compliance (M.48/1122)
- Laboratory Animal Cages and Recommended Stocking Density (M.47/1122)
- Humane Endpoints (M.46/1122)
- Enrichment Program for Laboratory Animals (M.74/922)
- Respiratory Protection Policy (M.72/922)
- Unexpected Adverse Event Assessment and Reporting Plan (M.60/922)
- Blood Collection SOP (M.51/1120)
- Mouse Identification and Genotyping Policy (M.48/1120)
- Food and Fluid Restriction in Research Animals Policy (M.47/1120)
- Welfare and Use of Animals in Cancer Research Policy (M.45/1120)
- Social Housing of Social Species Policy (M.44/1120)
- Multiple Survival Surgery Policy (M.15/620)
- Use of Non-Pharmaceutical Grade Drugs Policy (M.14/620)
- Restraint of Conscious Animals Policy (M.18/620)
- Conscientious Objection Policy for Teaching Experiments Involving the Use of Live Animals (M.169/209)
Reports on Protocol Approval
- 01 Jan 2022 – 30 Jun 2022 (Note: Reporting period standardised as from 2022 due to CARES)
- 01 May 2021 – 31 Mar 2022
- 01 Nov 2020 - 30 Apr 2021
- 01 May 2020 - 31 Oct 2021
- 01 Jul 2019 - 30 Apr 2020
- 01 Nov 2018 - 30 Jun 2019
- 01 Jan 2018 - 31 Oct 2018
- 01 Feb 2017 - 31 Dec 2017
- 01 Mar 2016 - 31 Jan 2017
- 01 Jun 2015 - 29 Feb 2016
- 01 Dec 2014 - 31 May 2015
- 01 Jun 2013 - 31 May 2014
- 01 Nov 2012 - 31 May 2013
- 01 Mar 2012 - 31 Oct 2012
- 01 Aug 2011 - 29 Feb 2012
- 01 Dec 2010 - 31 Jul 2011
- 01 Apr 2010 - 30 Nov 2010
- 01 Nov 2009 - 31 Mar 2010
- 01 Mar 2009 - 31 Oct 2009
- 01 Sep 2008 - 28 Feb 2009
- 01 Mar 2008 - 31 Aug 2008
- 01 Aug 2007 - 29 Feb 2008
- 01 Jan 2007 - 31 Jul 2007
- 01 Apr 2006 - 31 Dec 2006
- 16 Oct 2005 - 31 Mar 2006
- 16 Mar 2005 - 15 Oct 2005
References for Completion of the CULATR Application Form
- CCAC Guidelines on the Care and Use of Wildlife, Canadian Council on Animal Care
- Center for Alternatives to Animal Testing (Altweb)
- Code of Practice for the housing and care of animals used in scientific procedures, 2014, Home Office, UK
- CULATR Policy on Multiple Survival Surgery
- CULATR Policy on the Restraint of Conscious Animals
- CULATR Policy for the Social Housing of Social Species
- Fund for the Replacement of Animals in Medical Experiments (FRAME)
- Guidance on the housing and care of the African clawed frog Xenopus laevis
- Guidelines for the Use of Fishes in Research, American Fisheries Society
- International Guiding Principles for Biomedical Research Involving Animals, ICLAS and CIOMS
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- National Centre for the Replacement, Refinement and Reduction of Animals in Research: ARRIVE guidelines
- Norwegian Reference Centre for Laboratory Animal Science and Alternatives (NORINA)
- Report on the Study of the Effects of Stocking Density on the Performance and Well-being of Mice (LAU)
- The Principles of Humane Experimental Technique, William M.S. Russell & Rex L. Burch (1959)
- 3Rs – Reduction (experimental design)
Section 7
- The Design of Animal Experiments: Reducing the Use of Animals in Research through Better Experimental Design (RSM, 2002)
(available at the Yu Chun Keung Medical Library; call number: M616.0273 D4) - Principles of Experimental Design for the Life Sciences (CRC Press, 1996)
(available at Hing Wai Storage; call number: D610.72 S46) ) - Statistics and Experimental Design for Toxicologists (Third Edition) (CRC Press, 1999)
(available at Main Library; call number: 615. 900727 G123 s) - Statistics for Experimenters: Design, Innovation, and Discovery (Second Edition) (John Wiley & Sons. Inc.)
(available at Yu Chun Keung Medical Library: call number: M001.424 B78 s) - Experimental Design for Biologists (Cold Spring Harbour Laboratory Press, 2007)
(available at Yu Chun Keung Medical Library: call number: M570.724 G54)
Section 11
- Saphenous vein puncture for blood sampling of the mice (2005)
- The UKCCCR guidelines for the welfare of animals in experimental neoplasia (1997)
- Home Office Guidance Note: Water and food restriction for scientific purposes (2003)
- Home Office Guidance Note: Antibody production – Principles for protocols of minimal severity (2000)
- CCAC Guidelines on Antibody Production, Canadian Council on Animal Care (2002)
- Refinement and reduction in production of genetically modified mice (2003)
- Laboratory birds: refinements in husbandry and procedures (2001)
- Refining procedures for the administration of substances
- ILAR Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research (2003)
- Guide for the Care and Use of Laboratory Animals, NRC, USA (2011)
- NIH Guidelines for Research Involving Recombinant DNA Molecules
- AFCD Code of Practice for Care and Use of Animals for Experimental Purposes (2004)
- Veterinary Care for Laboratory Animals, Centre for Comparative Medicine Research, HKU (2020)
- NIH Guidelines for Survival Rodent Surgery, USA (2017)
- Harmonisation of Animal Care and Use Guildlines, Science (2006)
- NIH Guidelines for Ascitis Production in Mice (2016)
- Sub-mandibular bleeding of mice (2005)
Section 11(c)
- Pain and distress in laboratory rodents and lagomorphs, Laboratory Animals 28, 97-112 (1994)
- Handbook of laboratory animal management and welfare, S. Wolfensohn et al (2003)
(available at the Main Library; call number: 636.0885 W855 h) - Formulary for laboratory animals, C.T. Hawk et al (2005)
(available at the Yu Chun Keung Medical Library; call number: M 636.089514 F72) - Laboratory animal anaesthesia, P. Flecknell (1996)
(available at HKU Library; call number: 636.0885 F5) - Anaesthesia and analgesia in laboratory animals, D.F. Kohn et al (2008)
(available online via HKU Library: http://library.hku.hk/record=b4166538) - Guidelines for animal surgery in research and teaching, Am J Vet Res, 54, 1544-1559 (1993)
available at www.lib.hku.hk - Pain management in animals. P. Flecknell & A. Waterman-Pearson (2000)
(available at the Yu Chun Keung Medical Library; call number: M 636.08960472 P1) - The assessment and alleviation of pain and distress in research animals (2007)
Section 11(e)
- CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing (1998)
- ILAR Report: Humane endpoints for animals used in biomedical research and testing (2000)
- NIH Guidelines for Endpoints in Animal Study Proposals, USA (2016)
- Guidelines for the Assessment and Management of Pain in Rodents and Rabbits, ACLAM (2006)
Section 11(j)
- AVMA Guidelines for the Euthanasia of Animals (2013 Edition)
- NIH Guidelines for the Euthanasia of Rodent Fetuses and Neonates (2016)
- NIH Guidelines for Euthanasia of Rodents Using Carbon Dioxide (2017)
Section 11(k)
Other References
- CCAC Guidelines on the Care and Use of Wildlife, Canadian Council on Animal Care (2003)
- Code of Practice for the housing and care of animals used in scientific procedures, 2014, Home Office, UK
- Guidelines for the Use of Fishes in Research, American Fisheries Society (2014)
- The Principles of Humane Experimental Technique, William M.S. Russell & Rex L. Burch (1959)
- Guidance on the housing and care of the African clawed frog Xenopus laevis (2005)
- International Guiding Principles for Biomedical Research Involving Animals, ICLAS and CIOMS (2012)