Research Projects
Bioinformatics in Liver Cancer


Programme(s) to which this project applies:
☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

The application of single-cell RNA sequencing (scRNA-seq) to delineate tissue heterogeneity and complexity has become increasingly popular. Given its tremendous resolution and high-dimensional capacity for in-depth investigation, scRNA-seq offers an unprecedented research power. It is particularly useful in cancer research, where tumour tissue has a highly admixed cell population and hence is difficult to study. Although some software packages are available for scRNA-seq data analysis and visualization, it is still a big challenge for their usage, as they require significant level of bioinformatics skills. Hence, there is an urgent need for comprehensive software packages with graphical user interface to facilitate scRNA-seq studies.

Professor DWH Ho, Department of Pathology

My research focuses are bioinformatics analysis on high-throughput omics data and computational analysis tools development. I have particular interests on genomics studies of hepatocellular carcinoma (HCC) through the application of next generation sequencing, large-scale screening, liquid biopsy and single-cell genomics. I am also involved in multidisciplinary and integrative studies to investigate and understand the molecular mechanism of hepatocarcinogenesis and metastasis of HCC.

Biography
HKU Scholars Hub
dwhho@pathology.hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information. 

Research @ Department of Pathology