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Programme(s) to which this project applies: |
| ☑ MPhil/PhD | ☒ MRes[Med] | ☒ URIS |
About the Project
The accumulation of senescent cells over time drives chronic inflammation and tissue dysfunction, serving as a primary driver of the aging process. Inspired by recent breakthroughs in immunology, this pioneering project seeks to develop novel "anti-aging vaccines" that train the host's immune system to proactively recognize and clear harmful senescent cells.
The research will unfold in two main phases: First, we will identify and characterize senescence-associated antigens—specific proteins that are selectively expressed on the surface of, or secreted by, senescent cells. Second, we will formulate immunogens and vaccine delivery systems designed to provoke a robust, targeted adaptive immune response against these specific antigens. By conceptually vaccinating against the molecular drivers of aging, we aim to harness adaptive immunity to systematically eliminate senescent cells, thereby rejuvenating tissue microenvironments and reversing the detrimental effects of aging across various organ systems.
About the Supervisor
Dr Q Zhang, School of Biomedical Sciences
Qingqing Zhang is a Research Assistant Professor at the School of Biomedical Sciences at the University of Hong Kong. Qingqing Zhang received a Ph.D. from the Department of Obstetrics and Gynaecology at the University of Hong Kong. Dr. Zhang did her postdoc training for reproductive ageing and placental ageing at the Department of Obstetrics and Gynaecology, HKU.
Next Step?
For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description. Interested candidates are advised to enclose with your email:
- your CV,
- a brief description of your research interest and experience, and
- two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).
Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.
HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.
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