Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Liver cancer is one of the most common cancer and is particular prevalent in Hong Kong and Mainland China. Liver carcinogenesis is a stepwise progress that traditionally attributed to the accumulation of genetic mutations. Recently, growing evidences have suggested that epigenetic deregulation is playing an equally important role in liver carcinogenesis. Epigenetics, as implied by the Greek prefix, epi- (means “in additional to”), refers to an additional regulatory layer on top of the genetic information stored as DNA sequences. Epigenetic regulation is principally mediated through various heritable modifications at nucleotide, histone, and chromatin levels, but without altering the DNA sequence per se. DNA methylation, histone modifications, and chromatin remodelling are three major mechanisms of epigenetic regulation in mammalian cells. The three epigenetic regulatory mechanisms work intimately to determine local higher-order chromatin structure, and thereby switching “on” and “off” gene expression across the genome. Deregulated epigenetic machinery may lead to malignant transformation and cancer development. We are interested to explore the aberrant epigenomic landscape (i.e. DNA methylation, histone modification, and chromatin remodelling) in liver cancer using different next-generation sequencing techniques. We are also interested to dissect the functions of different epigenetic regulators in liver cancer using different functional assays. Finally, we will also employ different in vitro and animal models to test the therapeutic potential of small molecular inhibitors targeting epigenetic regulators in liver cancer. This study will shed light to the underlying molecular mechanisms of liver carcinogenesis and pave the way for the development of novel treatment strategy for liver cancer.
Dr JCM Wong, Department of Pathology
Dr Chun-ming Wong is an associate professor of the Department of Pathology and a Principal Investigator of the State Key Laboratory of Liver Research. He is keen on investigating the genome and epigenome of liver cancer and is one of the pioneers working on RNA modification and liver cancer.
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