Research Projects
Treatment outcomes of ADHD children with clinical, neurocognitive and gut microbiome measurement

This is a cohort study aiming to examining treatment outcome of ADHD children (aged 6-12 years) on ADHD and other psychiatric-symptom severity, study and functional outcomes, and neurocognitive performance, as well as caregivers' burden and distress after initiation of medication therapy. In particular, a comprehensive battery of neurocognitive assessment will be conducted to evaluate whether ADHD children's performance on impulsivity, sustained attention, delayed gratification, and other relevant cognitive domains would be improved with treatment. Data on gut microbiome is also collected to examine the potential value in outcome prediction. Given the significant impact of ADHD symptoms and related behavioral manifestations on children's academic and daily functioning, this study will facilitate better understanding of the course and factors in relation to treatment response in this vulnerable population and their caregivers, and subsequent development of tailor-made effective strategies to further improve overall outcome.

Professor WC Chang, Department of Psychiatry

Professor WC Chang is a Clinical Associate Professor and Department Chairperson of the Department of Psychiatry at the School of Clinical Medicine, LKS Faculty of Medicine and a Principal Investigator of the State Key Laboratory of Brain & Cognitive Sciences, University of Hong Kong. He is a Fellow of the Royal College of Psychiatrists (UK), the Hong Kong College of Psychiatrists, Vice-President of the HK College of Psychiatrists and Member of the Advisory Committee on Mental Health of the Health Bureau. Professor Chang’s research interests include early intervention for psychosis, outcomes of schizophrenia and bipolar disorder, clinical high-risk and psychosis prediction, negative symptoms, reinforcement learning and related paradigms for amotivation, as well as the impact of major mental disorders and psychotropics on physical health outcomes. He has published more than 200 articles in international peer-reviewed journals, including more than 70 first-/corresponding authored articles and 6 book chapters. He has been a HKU Scholars in the Top 1% for 5 consecutive years since 2019, and has received several research awards including such as the Early Psychosis Association Young Investigator Award, and the NARSAD Young Investigator Award by Brain & Behavior Research Foundation.

Biography
HKU Scholars Hub
Lab Homepage
ORCID
changwc@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

1. your CV,
2. a brief description of your research interest and experience, and
3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.