Research Projects
The alternative splicing in high grade serous ovarian cancer


Programme(s) to which this project applies:
☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

Alternative splicing of mRNA is a key cellular mechanism which increases the diversity and complexity of gene expression by generating multiple protein isoforms. Dysregulation in alternative splicing (AS) has been found to drive the initiation and progres. We aim to identify novel AS in HGSOC and investigate their translational potentials.
We will analyse long-read RNAseq data from HGSOC tumours and non-malignant tissues, using a combination of bioinformatics pipelines, and identify novel AS dysregulated in HGSOC. AS events and their regulators with potential therapeutic potential will be selected for downstream characterisation.
The candidate will receive training in bioinformatics, molecular and cell biology, and cancer biology techniques.

Professor HN Lu, Department of Obstetrics and Gynaecology

Professor Lu is a Assistant Professor in the Department of Obstetrics and Gynaecology. He has an interest in cancer genomics, tumour-microenvironment interaction, and novel therapeutic strategies in gynaecological cancers.

Biography
ORCID
haonanlu@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information. 

Research @ Department of Obstetrics and Gynaecology