Research Postgraduate Studies
Department of Obstetrics and Gynaecology


Department of Obstetrics and Gynaecology


Research Questions

  • Through the cutting-edge application technologies such as whole-genome and methylome sequencing analyses in clinical samples, which and how the putative driving genes are involved in cancer development and progression?
  • What are the underlying mechanisms in the tumour-stromal crosstalk network that enhance ovarian cancer metastatic colonisation?
  • How could fertilisation, endometrial regeneration, embryo implantation and placentation be regulated?
  • Is there any in vitro and in vivo model to study fertility, stem cells differentiation and interaction, embryo implantation and post-implantation?
Researcher at the Department of Obstetrics and Gynaecology

1. Oncology

Our gynae-oncology research team aims to carry out bench to bedside cancer research. Current areas of basic research concentration on are epidemiology of human papillomavirus (HPV) and cervical cancer, genetic/epigenetic alterations in cancer development and progression, cancer stem cells (CSC), cancer cell metabolism, onco-immunology, interactions between cancer cells and the tumour microenvironment in tumorigenesis, chemo-resistance, and metastasis of gynaecological malignancies. These studies hope to provide a scientific basis for developing novel diagnostic tools and therapeutic interventions for improving treatment outcome of gynaecological cancer patients.

  

2. Reproduction

The Reproductive Medicine Division is recognised by both the Royal College of Obstetricians and Gynaecologists and Hong Kong College of Obstetricians and Gynaecologists for subspecialty training in Reproductive Medicine. It provides both clinical and basic research opportunities to postgraduate students. The Division is actively collaborating with a number of centres in Mainland China and other countries on various aspects of reproductive medicine. Current research topics includes the Use of hormone replacement therapy (HRT) in Hong Kong Chinese women; menopause and hormone replacement therapy; implantation model and endometrial receptivity; assisted reproduction and pregnancy outcome prediction; interaction between embryo/gamete and female reproductive tract; placental development; miRNA on fertilization and stem cell differentiation; medical abortion and contraception.

  

3. Maternal-Foetal Medicine

  • Epidemiology of gestational diabetes mellitus in Chinese patients;
  • dietary manipulation in the treatment of diabetes in pregnancy;
  • predictors of preterm delivery; group B Streptococcus screening;
  • ultrasonographic assessment of pregnancies at risk of alpha thalassaemia major;
  • early intrauterine physiological changes of Hb Bart's disease;
  • biochemical and ultrasound screening for foetal Down's syndrome;
  • haematopoietic stem cell culture from umbilical cord blood;
  • 3-dimensional ultrasound for foetal anomalies and growth;
  • use of 3-dimensional/4-dimensional ultrasound in prenatal diagnosis;
  • expression of granulin-epithelin precursor during pregnancy;
  • foetal DNA/RNA in maternal serum.

  

Supervisor(s)

Professor WSB Yeung

For more information or to express interest to join the research areas, please email the supervisor or the specified contact point in the description. Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Research postgraduate studies enquiries specific to the department/school’s research should be directed to the Chairman of the Departmental Research Postgraduate Committee:

Professor WSB Yeung
wsbyeung@hku.hk

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.

Our Students

WANG Huogang

Place of Origin: China
Progress: PhD Year 3
Supervisor: Dr CN Chiu

專注於卵巢癌臨床研究的王伙剛表示:「卵巢癌在早期是可以被治癒的,但絕大部分的卵巢癌病例發現時已癌變成晚期。在早期很難被檢測出來,而到了晚期癌細胞開始擴散轉移,是導致大部分人死亡的原因。」

王伙剛下一步研究如何在這種富含脂質的微環境當中激活這些免疫細胞,讓他們重新行使抗腫瘤的功能。

「當研究上有所進展,但臨床上暫時還得不到應用時,會更加激勵自己持之以恆往這個方面去努力,那麼遲早會研究出一個可以應用在臨床上的技術,幫助人們緩解病痛。這讓我感覺我所做的事情很有意義,也是支撐着我在醫學之路探索的動力所在。」

July 2021