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Programme(s) to which this project applies: |
| ☑ MPhil/PhD | ☑ MRes[Med] | ☑ URIS |
About the Project
Objective and Significance:
To improve the understanding of immune responses to antigens, vaccination, infectious agents, and allergens in inborn errors of immunity and immunocompetent hosts with different ages.
To apply cutting edge methodologies such as whole genomic sequencing, bulk and single-cell mRNA sequencing, proteomics, CyTOF, and systems serology assays to study cellular and humoral immune responses in a comprehensive and detailed manner.
To provide scientific and clinical evidence to support the use of novel vaccines at different age groups, including healthy children and children with immunocompromised states, and adults with vaccine seroconversion failures.
Research Plan and Methodology:
We have an immunobridging study on BNT162b2 and CoronaVac in children and adolescents (NCT04800133). There is a longitudinal study on measles booster vaccination in young adults with secondary vaccine failure. Other vaccine studies and trials are also underway or will begin soon. Studies on inborn errors of immunity and allergic conditions are ongoing. For enquiries please liaise with Daniel Leung MBBS/PhD at dan.leung@hku.hk and/or Jeffery Chan MBBS/MRes[Med] at ching121@connect.hku.hk.
About the Supervisor
Prof Yu Lung Lau, Department of Paediatrics and Adolescent Medicine
About the Supervisor
Prof Jaime S Rosa Duque, Department of Paediatrics and Adolescent Medicine
Next Step?
For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description. Interested candidates are advised to enclose with your email:
- your CV,
- a brief description of your research interest and experience, and
- two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).
Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.
HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.
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