Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☑ URIS|
Severe mental disorders including schizophrenia (and related psychoses) and bipolar disorder affect 2-3% of the population and constitute one of the leading causes of disability worldwide. Better understanding of the early course of illness, in particular the trajectory of clinical, functional and neurocognitive impairment, is critical for development of targeted intervention to modify long-term prognosis. In the current study, we conduct a well-characterized early-stage psychotic disorder and bipolar disorder cohort study with an aim to systematically examine clinical (symptom assessments), functional, neurocognitive outcomes (standardized cognitive battery), and neuroimaging measures. The study results will facilitate development of more individualized risk model for treatment outcome prediction, and hence delivery of effective interventions to promote early recovery.
Dr WC Chang, Department of Psychiatry
Dr WC Chang is a Clinical Associate Professor and Department Chairperson of the Department of Psychiatry at the School of Clinical Medicine, LKS Faculty of Medicine and a Principal Investigator of the State Key Laboratory of Brain & Cognitive Sciences, University of Hong Kong. He is a Fellow of the Royal College of Psychiatrists (UK) and the Hong Kong College of Psychiatrists. Dr. Chang’s research interests include early intervention for psychosis, outcomes of schizophrenia and bipolar disorder, clinical high-risk and psychosis prediction, negative symptoms, reinforcement learning and related paradigms for amotivation, as well as the impact of severe mental illnesses on physical health. He has published 190 articles in international peer-reviewed journals, including 64 first-/corresponding authored articles and 4 book chapters. He has been a HKU Scholars in the Top 1% for 4 consecutive years since 2019, and has received several research awards including such as the Early Psychosis Association Young Investigator Award, and the NARSAD Young Investigator Award by Brain & Behavior Research Foundation.
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