Research Projects
Stem Cell Decline in SIRT6 Deficient Ageing Mice

Programme(s) to which this project applies:

☒ MPhil/PhD ☑ MRes[Med] ☒ URIS

Objective and Significance:

Understand how stem cells contribute accelerated aging and to investigate if the rescued accelerated aging by p53 deficiency restore stem cells in these SIRT6 deficient mice.

Research Plan and Methodology:

Wild-type, Sirt6-/- and Sirt6/-/P53+/- mice will be generated and their stem cells from different tissues will be examined. The underlying mechanisms of stem cells decline in Sirt6 deficient mice will be investigated and stress induced by DNA damage will be targeted to see if stem cells decline can be restored.

Professor ZJ Zhou, School of Biomedical Sciences


For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.