Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Vascular smooth muscle cells (VSMCs) play a critical role in the onset and progression of atherosclerosis. In pre-atherosclerotic lesions, there are stiffness changes of arteries due to vascular injuries or excess deposition of cholesterol plaques, and VSMC switches from a contractile to a synthetic phenotype. In particular, synthetic VSMC assembles the podosome as the invasive adhesion structure, migrates between different vessel layers, and promotes the pro-atherosclerotic matrix microenvironment. Rho GTPase is one of the master regulators of podosome assembly. We aim to investigate how matrix stiffness orchestrate the plasticity of VSMC by regulating Rho GTPase activation.
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Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to email@example.com.
HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.