Research Projects
Investigating Mutational Processes in Cancer Genomes

Programme(s) to which this project applies:

☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

Mutations in DNA are known to directly contribute to the development of cancers. In recent years, research, including those from our own group (Nature 2016, Cell Reports 2016, NAR 2017, PLoS Genetics 2018, PLoS Genetics 2020) have begun to shed light on mutational processes – linking mutagen exposure, DNA repair and epigenetic factors in governing how certain mutations form across cancer genomes. We currently have several projects that integrate computational, next-generation sequencing and mass spectrometry-based techniques to further our understanding of mutational processes. The outcomes of this project will not only further our fundamental knowledge of cancer mutational processes but will also have direct translational impact, potentially providing oncologist with new tools to select the most effective treatments for their patients.

We are seeking candidates with a strong interest in the fields of DNA damage/repair and cancer genomics. We are open to candidates with either computational or laboratory skills. Experience in mass spectrometry will be an advantage. All students can expect to develop skills in computational biology and bioinformatics.

Professor JWH Wong, School of Biomedical Sciences


For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.