Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Cancer invadopodia exhibit the unique protrusive F-actin network, degrade the extracellular matrix in proximity, and facilitate the invasive cell migration. It is postulated that this process is the mechanism used by carcinoma cells to gain access to the vasculature within connective tissue for dissemination throughout the body. Thus, any molecular target that inhibits invadopodium functionality will be a likely target for therapeutic exploitation. Several novel factors that can regulate the initiation and stabilisation of F-actin cytoskeleton have been identified. We aim to use the approach of molecular cell biology and quantitative fluorescence microscopy to uncover the underlying mechanism and to inhibit the assembly of invadopodia.
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HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.