Research Projects
Virus immediate-early transactivator IE1 re-distributes the host chromatin organization

Programme(s) to which this project applies:

☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

Host cell chromatin is generally redistributed upon virus infection, but the molecular mechanism remains unknown. In HCMV, the IE-1 chromatin-tethering domain can interact with the host H2A-H2B acidic patch and impair chromatin compaction. Meanwhile, AcMNPV IE1 could intriguingly induce the host cell chromatin rearrangement. These indicate an essential role IE-1 plays in the virus life cycle and the ability IE-1 has in the host chromatin reorganization. The goal of this project is to investigate the mechanism of how viral IE-1 impacts the host chromatin higher-order structure.

Dr Y Liu, School of Biomedical Sciences

LIU lab explores how epigenetic variations are incorporated and maintained in the genome, how epigenetic markers on histones are regulated by histone chaperones and chromatin remodelers in diseases, and how viral proteins affect the host chromatin structures and dynamics.


For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.