Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
Host cell chromatin is generally redistributed upon virus infection, but the molecular mechanism remains unknown. In HCMV, the IE-1 chromatin-tethering domain can interact with the host H2A-H2B acidic patch and impair chromatin compaction. Meanwhile, AcMNPV IE1 could intriguingly induce the host cell chromatin rearrangement. These indicate an essential role IE-1 plays in the virus life cycle and the ability IE-1 has in the host chromatin reorganization. The goal of this project is to investigate the mechanism of how viral IE-1 impacts the host chromatin higher-order structure.
Dr Y Liu, School of Biomedical Sciences
LIU lab explores how epigenetic variations are incorporated and maintained in the genome, how epigenetic markers on histones are regulated by histone chaperones and chromatin remodelers in diseases, and how viral proteins affect the host chromatin structures and dynamics.Biography
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HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
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