Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
FACT (facilitates chromatin transcription) contributes to the nucleosome reorganization during transcription. In particular, FACT is over-expressed in multiple cancer types and has been observed with the inactivation of the tumor suppressor protein P53. Onco-histones (histone mutations, variations and modifications) were reported to be present and de-stabilize the nucleosomes in cancer, leading to easier DNA access to transcription. However, whether FACT has a preference for onco-histones, what onco-histones FACT prefers, and how FACT regulates transcription in cancer cells are to be elucidated. The goal of this project is to decipher how FACT promotes transcription in cancer cells and the potential cancer therapies.
Dr Y Liu, School of Biomedical Sciences
LIU lab explores how epigenetic variations are incorporated and maintained in the genome, how epigenetic markers on histones are regulated by histone chaperones and chromatin remodelers in diseases, and how viral proteins affect the host chromatin structures and dynamics.Biography
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HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.