Research Projects
Mettl3-mediated m6A modification of Ndrg1 promotes acute kidney injury (AKI) sensitivity in diabetic nephropathy

The project aims to evaluate whether the Mettl3-mediated m6A modification of Ndrg1 promotes acute kidney injury (AKI) sensitivity in diabetic nephropathy. We will try to answer these questions:

(1) Does upregulation of Mettl3 in DN enhance AKI susceptibility?

(2) Does suppression of Mettl3 in DN attenuate AKI susceptibility?

(3) Is Mettl3-mediated Ndrg1 a major pathway to enhance AKI susceptibility?

(4) Does targeting Ndrg1 knockdown attenuate AKI in diabetic mice?

Professor HY Chen, School of Chinese Medicine

Biography
HKU Scholars Hub
Lab Homepage
ORCID
haiyong@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

1. your CV,
2. a brief description of your research interest and experience, and
3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.