Programme(s) to which this project applies:
|☑ MPhil/PhD||☒ MRes[Med]||☒ URIS|
The histone chaperone DAXX (death-domain associated protein) interacts specifically with its corresponding histone variant H3.3. Interestingly, the deposition of H3.3-H4 in heterochromatin is highly regulated by two known pathways specifically through DAXX. At peri-centromeres and telomeres, DAXX delivers H3.3 by forming a heterodimer with the ATP-dependent chromatin remodeler ATRX (Alpha-thalassemia/mental retardation syndrome X-linked protein). Moreover, DAXX also deposits H3.3 specifically at endogenous retrovirus elements in an ATRX-independent pathway, which involves the recruited histone writer SETDB1 and eraser HDAC. The mechanisms behind these two regulation pathways are to be determined. The goal of this project is to elucidate the interactions and effects of ATRX and other chromatin factors on DAXX-mediated H3.3 deposition.
Dr Y Liu, School of Biomedical Sciences
LIU lab explores how epigenetic variations are incorporated and maintained in the genome, how epigenetic markers on histones are regulated by histone chaperones and chromatin remodelers in diseases, and how viral proteins affect the host chromatin structures and dynamics.Biography
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