|
Programme(s) to which this project applies: |
| ☑ MPhil/PhD | ☒ MRes[Med] | ☒ URIS |
About the Project
Histone chaperone, as a promising molecular target for therapies, represents new opportunities in drug discovery. However, even though great advances have been made to elucidate complete histone chaperone pathways for histone deposition or eviction, there are gaps in our understanding of the molecular mechanisms of histone chaperones before using them as therapeutic targets. To fill this knowledge gap, our proposed research combines chemical proteomics and biochemical approaches to characterize the biological functions as C1QBP as a histone chaperone.
Objectives
I. To decipher the interaction mechanism of C1QBP-histone complex.
II: To characterize H4K12succ-mediated histone chaperone activity of C1QBP.
III: To explore the biological significance of C1QBP in vivo,
About the Supervisor
Dr XC Bao, School of Biomedical Sciences
Dr. Xiucong Bao, a Research Assistant Professor in the School of Biomedical Sciences, Faculty of Medicine.
Protein posttranslational modifications (PTMs) play essential roles in the regulation of almost all biological processes and the dysregulation of proteins PTMs often leads to human diseases. Our lab focuses on the development of chemical biological strategies to decipher the biological functions of protein post-translational modifications (PTMs) and their regulatory mechanisms in immune system. Our overall mission is to elucidate the fundamental mechanisms responsible for carcinogenesis and to translate basic biomedical discovery into effective therapies for immune diseases.
Next Step?
For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description. Interested candidates are advised to enclose with your email:
- your CV,
- a brief description of your research interest and experience, and
- two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).
Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.
HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.
HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.
Follow HKUMed