Research Projects
Effect of combination therapy for influenza


Programme(s) to which this project applies:
☑ MPhil/PhD ☑ MRes[Med] ☒ URIS

Current influenza treatment relies on mono therapy of different classes of antiviral agents. Combination therapy with different classes of antiviral agents or with immune modulatory agents may provide benefits in reducing viral loads and alleviating uncontrolled cytokine responses associated with severe influenza.

This project aims to: 

  1. Compare viral burden and the frequency of resistance variants emergence under mono and combination therapy of antiviral agents.
  2. Evaluate the host response upon combination therapy with antiviral agents and immune modulatory agents.

Professor HL Yen, School of Public Health

My research focuses on understanding the transmission mechanisms of influenza and other respiratory viruses, investigating potential virus-host interactions that affect viral pathogenicity and transmission, and examining the molecular determinants that confer antiviral resistance. A major research focus is to understand factors that facilitate emergence and spread of novel respiratory viruses within and between different reservoir hosts. We study viral determinants of interspecies transmission and works with a multidisciplinary team to study the transmission modes of influenza and other respiratory viruses in the field and in the laboratory.

Biography
HKU Scholars Hub
Lab
ORCID
hyen@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information. 

Research @ School of Public Health