Research Projects
AI-based protein design

Due to the rapid development of Artificial Intelligence, de novo protein design and engineering become more and more powerful. We aim to integrate the up-to-date algorithms on protein design to develop our pipeline for its application in biomedical sciences. The project will focus on designing small inhibitory proteins which target critical onco- proteins/complexes, and also design the molecular tools for epigenetic regulation studies. By establishing a high-throughput in vitro purification and screening system, we will train the AI model for better performance on protein design. We will leverage our expertise in structural biology to validate the designed proteins by solving the atomic structure through single particle cryoEM. We all collaborate with other labs or industry partners to further explore the efficacy of the protein function in vivo or in the industry application.

Professor K Zhou, School of Biomedical Sciences

Biography
kedazhou@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

1. your CV,
2. a brief description of your research interest and experience, and
3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.