Department of Surgery

Research Questions

  • Why are some people more prone to develop cancers?
  • How can we know the functions of a gene?
  • How can we trace cancer cells in mice?
  • How can we study human cancers in animals?
Researcher at the Department of Surgery

1. Breast Surgery

  • Breast cancer genetics, biomarkers and translational research
  • Advanced surgical technologies in management of breast disease and breast cancer
  • Epidemiological and psychosocial studies in breast cancer
  • Bio-engineering research in breast cancer
  • Oncological clinical trials

Professor A Kwong


2. Endocrine Surgery

  • Thyroid cancer and surgery
  • Parathyroid disease and surgery
  • Functional and non-functional adrenal tumours
  • Pancreatic neuroendocrine tumours
  • Thermal ablation of benign thyroid nodules
  • Value-based health care delivery

Professor BHH Lang


3. Oesophageal and Gastric Cancers

  • Animal cancer models
  • Treatment resistance mechanism
  • New biomarkers and treatments
  • Epigenetic studies
  • Bioimaging
Supervisor(s) Research Interest

Professor SYK Law

Oesophageal cancer

Professor KM Chu

Gastric cancer


4. Head and Neck Cancers / Plastic and Reconstruction Surgery / ENT

  • Swallowing dysfunction in head and neck cancer patients
  • Robotic surgery in head and neck area

Dr RKY Tsang


5. Head and Neck Cancers

  • Epigenetics
  • Immune responses
  • Biological therapy

Dr STS Wong


6. Liver Transplantation and Liver Regeneration

  • Transplant immunology and oncology
  • Fatty liver diseases and NASH
  • Biomarker, mechanism and treatment of disease recurrence after liver transplantation
  • Mechanism and therapeutic implication of liver regeneration

7. Liver Cancer

  • Cancer immunology and tumour microenviornment − mechanism and therapeutics
  • Hepatitis B recurrence − mechanism and therapeutics
  • NASH and cancer
  • Cholangiocarcinoma

8. Molecular Mechanisms and Therapeutic Targets of Hepatocarcinogenesis and Metastasis

9. Novel Immune Therapy and Immunoresistance Mechanism

10. Biomarkers for Post-operative Hepatocellular Carcinoma Recurrence

11. Prediction Models with the Application of AI and Bioinformatics


Professor K Man


12. Hepatocellular Carcinoma

  • Cancer genomics in hepatocellular carcinoma
  • Cellular mechanism in associating liver partition and portal vein ligation for staged hepatectomy or portal vein embolisation
  • Biomarkers, mechanisms and assessment of efficacy of immunotherapy for hepatocellular carcinoma

Dr ACY Chan


13. Neurooncology

  • To investigate and develop novel therapeutic approaches for the treatment of malignant glioma based on translational in vitro and in vivo laboratory experiments
  • Main foci:
    • Chemotherapy drug resistance
    • Tumour microenvironment
    • The role of innate immune response
    • Tumour metabolic functions and cell death pathways

14. Cerebrovascular Diseases

  • To investigate and develop novel therapeutic approaches for the treatment of intracerebral haemorrhage based on translational in vitro and in vivo laboratory experiments.
  • Main foci
    • Pathophysiology of demyelination and remyelination following haemorrhagic stroke
    • The role of innate immune response in haematoma resorption
    • Neuroprotective measures to improve functional outcome

Professor GKK Leung


15. Molecular Mechanistic Study of Developmental Disorders and Cancers Commonly Found in Children

  • Molecular basic study of biliary atresia
  • Molecular study of hepatobiliary system development
  • Molecular basic study of Hirschsprung's disease and other related neurocristopathies
  • Molecular study of enteric nervous system development
  • Molecular basic study of Congenital Pulmonary Airway Malformation (CPAM)

16. Translational Research of Birth Defects and Related Diseases

  • Genetics, stem cell and regenerative medicine: translating disease mechanism discoveries to treatment of biliary atresia
  • Towards precision diagnostics and regenerative therapies for Hirschsprung’s disease: from genomics to cells to tissues
  • Molecular genetic study of anorectal malformations
  • Childhood cancers

Professor PKH Tam

Professor KKY Wong

Dr PHY Chung

Dr VCH Lui

Dr CSM Tang


17. Stem Cells and Disease Modelling

  • Molecular bases of Hirschsprung's disease and other related neurocristopathies
  • Molecular study of enteric nervous system development in human and mouse
  • Neural crest stem cells biology
  • Human pluripotent stem cell-based cell- and organoid- models of genetic disorders
  • Tumour stem/initiating cells

Professor ESW Ngan


18. Nanomedicine

  • Nanomedicine in wound healing and regeneration
  • Development of new drugs and drug delivery systems using nanotechnology

19. Thoracic Disorders in Children

  • Understanding the pathogenesis of congenital pulmonary malformation
  • Using lung organoid technology as models for paediatric thoracic disease

20. Paedaitric Solid Tumours

  • High throughput new drug screening for cancer using 3D culture

Dr KKY Wong


21. Biliary Atresia: From Benchside to Bedside

22. Tissue Engineering in Paediatric Surgery


Dr HY Chung


23. Urology Cancer and Surgery

  • Mechanisms of tumourigenesis
  • Epigenetic studies
  • Biomarkers for renal cell cancers
  • Treatment for prostate cancer disease
  • Advanced prostate cancer diagnositics
  • Urolithiasis
  • Complex genito-urethral reconstruction
  • Innovative treatment for benign prostatic hyperplasia

Dr W Lam


24. Vascular Disease and Surgery

  • Pathogenesis, haemodynamics and endovascular treatment of aortic aneurysms and aortic dissections
  • Epidemiology and atherogenesis of peripheral arterial and venous diseases

Professor SWK Cheng

For more information or to express interest to join the research areas, please email the supervisor or the specified contact point in the description. Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Research postgraduate studies enquiries specific to the department/school’s research should be directed to the Chairman of the Departmental Research Postgraduate Committee:

Professor K Man

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to

Our Students

YANG Xinxiang

Place of Origin: China
Progress: PhD Year 4
Supervisor: Prof K Man


在學習的過程中,讓他認識到基礎科研為臨床帶來的正反饋。楊新祥關注到,人類一旦患上肝癌,體內攜帶的「自然殺傷細胞」(natural killer cell)就會功能變弱甚至失效。經過一系列的研究,他最終成功找出了讓自然殺傷細胞恢復功能的靶點,通過恢復身體的免疫功能來對抗肝癌。

September 2020