Research Postgraduate Studies
Department of Orthopaedics and Traumatology


Department of Orthopaedics and Traumatology


Research Questions

  • How does bone and joint remodelling associated with degeneration develop and can this be controlled to reduce disability?
  • Can biomaterials remodel tissue and organs regeneration in humans?
  • How can AI-integrated modelling improve the diagnosis and treatment?
Department of Orthopaedics and Traumatology
Research Areas

1. Orthopaedic Biomechanics and Biomaterials

  • Experimental approaches to investigate biomechanics of bone and joint
  • Biomechanical examinations of lumbar interbody fusion, new artificial intervertebral disc design and shape memory alloy in spine surgery
  • Finger fracture fixations, flexor tendon injuries and sports injuries biomechanics
  • Biomechanics of total hip replacement
  • Fixation implant design and development
  • Biomechanical evaluation of biomaterials
  • Cell biomechanics and micro/nano-biomechanics
  • Biomaterials for clinical applications
  • Novel bone substitutes and micro- or nano-biomaterials
  • Bioactive bone cement development

  

2. Molecular and Cellular Physiology and Regenerative Tissue Modelling

  • Nobel animal models of musculoskeletal disorders
  • Experimental scoliosis
  • Genetics of degenerative disc disease and osteoarthritis
  • Gene functions in articular and intervertebral joints
  • Proteoglycan metabolism in skeletal tissues
  • Bone healing and fracture repair
  • Genetic profiles of bone tumours and cell-biomaterial interfacial biology
  • Developing disease-modifying agents for treating joint degeneration
  • Programming stem cells or progenitors for joint regeneration
  • Role of fibrosis and its control in tissue repair and mesenchymal stem cell-based therapies

  

3. Clinical Data-Driven AI Modelling in Orthopaedics

  • Big data centre for large-scale population-based and epidemiological studies (back pain, disc degeneration, scoliosis)
  • Scoliosis screening
  • Surgical outcomes and predictive modelling
  • Risk factor assessment and prediction; novel imaging analytical models
  • 3 d image reconstruction
  • Ai biomarker fast-screening
  • "omics" modelling and analyses
  • Data capturing and complex regressions
  • Personalised modelling
  • Clinical patient and surgeon outcome medical models
  • Investigator initiated translational research projects with industry collaboration including
    1. Design, development, validation and regulatory application of novel osteoporotic fracture fixation devices
    2. Ai software development for machine learning based segmentation of bone models and bone biomechanics
    3. Design and validation of 3 d printed ai tools and implants.  Areas include automated and accurate bone modelling allowing fast 3 d geometry development
  • Novel point clouds trabecular bone simulation engine providing new tool for robust implant failing simulations and new implant designs
  • 3 d modelling and printing for personalised medicine i.e. pre-operative planning and intra-operative guidance for advanced trauma, spine and joint operations

  

4. Clinical Neurophysiology and Neural Engineering in Orthopaedics

  • Neurophysiological detection, neuroimaging, and neurorehabilitation in orthopaedics and spinal disorders
  • Bioelectrical engineering and biomedical devices in orthopaedics

  

Supervisor(s)

Professor WW Lu

Next Step?

For more information or to express interest to join the research areas, please email the supervisor or the specified contact point in the description. Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Research postgraduate studies enquiries specific to the department/school’s research should be directed to the Chairman of the Departmental Research Postgraduate Committee:

Professor WW Lu
wwlu@hku.hk

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.

Our Students

HSU Yu-ching

Place of Origin: Taiwan
Progress: PhD Year 3
Supervisor: Dr VYL Leung

“Patience and perseverance goes a long way on your research journey” 

After beginning her research postgraduate career here at HKUMed, Yu-Ching Hsu (Year 3 PhD student in Department of Orthopedics and Traumatology) quickly found herself surrounded by a group of self-driven colleagues who served to be a great source of motivation, but also pressure to perform well, “The research culture here is that everybody is working so hard! The stress sometimes can be a little overwhelming”.

With her research centred on understanding the etiology and pathogenesis of human intervertebral disc degeneration, a typical day in the lab can entail a variety of tasks i.e. refreshing cell culture medium, cell compression, other molecular research steps such as RNA extraction and real-time PCR. Though lab work can be, in her own words, “not always joyful”, Yu-Ching also advises any future prospective researchers to trust the process. 

“Sometimes you may feel bored or even frustrated with failure, but it doesn't mean you are wrong. Just be patient, let all the negative feelings go - keep on trying – until you finally reach your goal."  

June 2021