• Pluripotent stem cell for disease modelling and treatment of cardiovascular disease
  • Tissue engineering for treatment of heart failure
  • Small and large animal models for studying the mechanism and treatment of hypertension and heart failure
  • Cardiac arrhythmia − mechanisms and treatment of atrial fibrillation and ventricular arrhythmias
  • Cardiac pacing − developments in novel pacing technologies for treatment of heart failure and cardiac arrhythmia
  • Sudden cardiac death − epidemiology, prevention and treatment
  • Precision medicine for coronary heart disease − prediction of coronary artery disease using genetic and multi-omic approaches
  • Cardiovascular imaging − development of novel echo and MRI imaging for cardiovascular diseases

Professor HF Tse

  • Artificial intelligence and deep learning in cardiovascular diseases
    • Artificial intelligence and deep learning: is machine better than man in cardiovascular imaging: echocardiography, computed tomography, MRI and invasive imaging?
    • How can artificial intelligence enhance risk prediction in different cardiovascular disease?
    • Artificial intelligence: Deep machine learning and its integration in cardiovascular disease using a well-established population based database
  • Big data research on cardiovascular diseases
    • Heart failure – disease pattern, risk prediction and drug safety
    • Myocardial infarction – risk prediction and drug safety
    • Diabetes mellitus – cardiovascular risk prediction and drug safety
    • Atrial fibrillation – disease pattern, risk prediction and drug safety
    • Valvular heart disease – integration with echocardiography and advanced imaging for risk prediction and disease characterisation

Professor KH Yiu

  • Molecular genetics and pathogenesis of atherosclerosis, diabetes and diabetic complications;
  • clinical and basic studies on obesity and adipocyte-derived hormones
  • adipose tissue browning, immunometabolism
  • pathogenesis and management of autoimmune thyroid disease
  • genetics and environmental determinants of osteoporosis

Professor KCB Tan

  • Natural history and risk factors for development of disease complications of chronic hepatitis B infection
  • Virology and novel markers for hepatitis B disease
  • Novel treatment for chronic hepatitis B infection
  • Diagnostic tools and disease characterization of occult hepatitis B infection

Professor MF Yuen

  • Helicobacter pylori − disease pathogenesis, antibiotics resistance, gastric carcinogenesis
  • Stomach and colon cancer − chemoprevention, innovations on screening and surveillance
  • Gastrointestinal bleeding − prevention and intervention
  • Inflammatory bowel disease: epidemiology and treatment outcome

Professor WK Leung

  • What factors alter disease outcomes in treatment-predominant chronic hepatitis B?
  • What are the viral and host factors that predict treatment response in novel emerging therapies for chronic hepatitis B?
  • What are the underlying molecular mechanisms for different phenotypes of non-alcoholic fatty liver disease?
  • How can we diagnose liver fibrosis non-invasively and apply to clinical use?
  • What are the disease entities affected by gut microbiota dysbiosis?
  • Can faecal microbiota transplantation in animal models provide a causative answer to disease outcomes?
  • Artificial intelligence and deep learning: is machine better than man?
  • How can artificial intelligence enhance prediction of disease outcomes in different liver diseases?
  • Chronic hepatitis B: Translational and clinical studies on treatment outcomes and functional cure
  • Non-alcoholic fatty liver disease: Animal models and molecular mechanisms
  • Liver fibrosis: Novel non-invasive diagnostic techniques and clinical outcomes
  • Gut microbiota and faecal microbiota transplantation: Animal models and associations with disease outcomes
  • Artificial intelligence: Deep machine learning and its integration in liver disease

Professor WWK Seto

Clinical protocols for treatment of leukaemia and lymphomas; detection of minimal residual disease and molecular mechanisms in haematologic malignancy; clinical protocols for bone marrow transplantation; infective and neoplastic complications of bone marrow transplantation; molecular genetics of haematological malignancies; basic research in pathogenesis of blood cancers; normal and leukaemic haematopoietic stem cell study using NOD/SCID mice; embryonic haematopoiesis and gene regulation studies in zebrafish.


Professor YL Kwong

Professor AYH Leung

Development of novel diagnostic techniques (including non-invasive prenatal diagnosis and pre-implantation diagnosis) for common genetic diseases, such as thalassemias, haemophilias, Duchenne muscular dystrophy, spinal muscular atrophy and Huntington’s disease; genome-wide scan with microsatellite markers for linkage of new disease genes; development of DNA microarray technology to diagnose and elucidate the molecular pathology of genetic diseases and cancers.


Professor YL Kwong

  • Influenza − rapid diagnostics, vaccination and antiviral treatment (mouse models and clinical trials)
  • Pneumococcal disease − rapid diagnostics and vaccination (clinical trials)
  • Respiratory viruses − parainfluenza virus, metapneumovirus, rhinovirus, coronavirus, adenovirus (clinical presentation and antiviral treatment in mouse models and clinical trials)
  • Multiple drug resistance organisms − infection control and treatment

Professor IFN Hung

  • Molecular and immunological pathogenic mechanisms of renal inflammation and fibrosis in glomerular and tubulointerstitial diseases, with special focus on lupus nephritis
  • Translational studies on peritoneal mesothelial cell biology focusing on inflammation and fibrosis of peritoneal membrane in the context of peritoneal dialysis

Professor DTM Chan

  • Cellular and molecular mechanisms of proteinuric tubulointerstital disease, diabetic kidney disease and IgA nephropathy
  • Stem cell and regenerative medicine in diabetic and non-diabetic models of kidney disease
  • Integrative medicine in diabetic kidney disease, clinical and basic

Professor SCW Tang

  • Experimental stroke models; neuroimaging of stroke; biomarkers for stroke; high resolution EEG; functional brain mapping

Professor RTF Cheung

  • Neuroimmunology and Neuroinflammation − clinical, neuroradiological, molecular, immunological and pathological studies of 1) autoimmune and immune-mediated neurological disorders including neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS), autoimmune encephalitis, autoimmune myasthenia gravis and paraneoplastic neurological disorders; and 2) Alzheimer's disease (AD) aiming at development of novel therapies with anti-inflammatory and neuroprotective properties in NMOSD, MS and AD by cell and animal models as well as human clinical trials
  • Intracerebral haemorrhage with specific focus on intracerebral haemorrhage complicating therapy with anticoagulants and antiplatelet agents

Dr KH Chan

  • Epidemiology and clinical studies in primary and secondary prevention of stroke
  • Use of novel neuroimaging techniques to better understand the mechanisms and prognosis of stroke and cerebral small vessel disease
  • Role of the gut microbiota in vascular and brain health
  • Use of digital health technologies to improve the management of stroke

Dr GKK Lau

  • Lung cancer – early detection and screening for lung cancer; molecular genetics; circulating tumour markers; environmental risk factor and genes interaction in pathogenesis; novel therapeutics in lung cancer; lung nodule and biomarkers
  • Chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis – basic and clinical research 
  • Obstructive sleep apnoea
  • Lung function studies

Professor DCL Lam

  • Systemic lupus erythematosus (SLE) and other autoimmune diseases
  • Is SLE a single disease entity or a collection of autoimmune disorders?
  • Genetic and genomic studies of systemic lupus erythematosus
  • Evaluation of the Lupus Low Disease Activity State as an outcome measure of systemic lupus erythematosus
  • Treatment response measure in systemic lupus erythematosus
  • Amyotrophic dermatomyositis and anti-MDA-5 antibody syndrome

Professor CS Lau

  • What are the molecular and cellular defects and the underlying mechanisms in immune cells that contribute to the development of lupus?
  • What are the potential roles of non-coding RNAs as immune regulators and biomarkers for SLE?
  • What is the role of AIM2 inflammasome in lupus?
  • How can we exploit the lupus-associated molecular defects as tools for predicting disease progression and treatment response in patients?
  • Molecular and cellular dysregulation in systemic lupus erythematosus
  • Immunobiology of innate immune receptors

Dr VSF Chan

  • Drug allergy: epidemiology, clinical characteristics and diagnostics
  • Anaphylaxis: epidemiology, management, specific syndromes and healthcare intervention
  • Immunotherapy: Allergen immunotherapy and immunological changes with use of immune checkpoint inhibitors
  • Primary and Secondary Immunodeficiences: Diagnostics and cost-effectiveness of subcutaneous immunoglobulin in Hong Kong
  • Hereditary Angioedema: Genetics, clinical modifiers, therapeutics and Hong Kong HAE registry

Dr PH Li

Find Out More

Information on selected projects or research areas: Interested candidates are advised to email the relevant supervisors.  Please enclose with your email: (i) your CV, (ii) a brief description of your research interest and experience, and (iii) two reference letters (reference letters not required for HKUMed UG students seeking MRes[Med] or URIS projects)

Research studies enquiries specific to the Department/School’s research should be directed to the Departmental Research Postgraduate Advisor: Prof A Xu ( amxu@hku.hk)

Information on the research programme, funding support and admission requirements could be found on the RPg Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.

Meet Our Students

WANG Dandan

Place of Origin: China
Progress: PhD Year 3
Supervisor: Prof AYH Leung



October 2020 

SHEN Jialing

Place of Origin: China
Progress: PhD Year 4
Supervisor: Dr CM Wong

沈佳玲認為無法解釋的癌變可能與表觀遺傳學有關。肝病研究國家重點實驗室(香港大學)專門從事尖端的實驗室基礎研究,為乙型肝炎病毒感染、肝硬化、肝癌等找出更好的診斷方法和更新、更佳的療法。在申請博士前,她通過在線平台與港大醫學院導師初步接觸,被實驗室的學術氛圍深深打動, 再考慮到其研究長處與自己的興趣點難得地契合,沈佳玲投遞出攻讀博士的申請。


August 2020 


Place of Origin: Hong Kong
Progress: Graduated in 2019
Supervisor: Professor AYH Leung

Third-year PhD student Bowie Cheng lights up whenever she talks about the zebrafish she uses in her cancer research. “Zebrafish are great animal models because 70% of their genes are the same as ours. They have a fast growth cycle - developing from egg to fish in just 12 hours - so we get the experiment results pretty quickly. The transparency of their body is also an asset for researchers,” she says.

Bowie has been studying how the combinations of different mutated genes affect patients of acute myeloid leukemia, one of the most fatal cancers. “I hope to learn more and eventually apply my knowledge to the study of other types of cancer,” she adds.

August 2019