Department of Clinical Oncology


Research Questions

  • How do cancer cells evade attacks from the immune system?
  • How do cancer stem cells contribute to the transformation of normal tissue to malignant forms?
Researcher at the Department of Clinical Oncology
Research Areas

1. Clinical Research

Advanced radiotherapy techniques intensity modulated radiotherapy; stereotactic radiotherapy using tomotherapy, cyberknife and autosegmentation; nasopharyngeal carcinoma, especially its relationship with the Epstein Barr virus and immunotherapy including T cell treatment; multimodality treatment that aims at improving control and minimising side effects; multimodality treatment of brain tumours, colorectal, oesophageal cancer, breast cancer, and thyroid cancer, and elucidation of related prognostic factors.

  

2. Identification and Characterisation of Cancer-Related Genes

Elucidation of the tumour pathogenesis and progression in hepatocellular carcinoma (HCC), nasopharyngeal carcinoma (NPC), colorectal cancer, oesophageal cancer, ovarian cancer, and lung cancer, through the characterization of isolated oncogenes or tumour suppressor genes with recently-developed techniques, such as next-generation sequencing analysis. Functional assays are used to study the roles of candidate genes in cancer development and progression.

Supervisor(s)

Professor AWM Lee

Professor DLW Kwong

Professor SFM Kong

Professor XY Guan

  

3. Discovery and Validation of Candidate Genes in Nasopharyngeal and Oesophageal Cancers

  • Understanding the molecular genetic basis of human cancers through molecular, functional, and whole-genomic next-generation sequencing approaches to understand genetic susceptibility and molecular landscape of tumour development
  • Identification and validation of biomarkers in tissues and liquid biopsies for translation into clinical practice
  • Research opportunities for basic, translational, and clinical studies focused on nasopharyngeal carcinoma (NPC) and oesophageal squamous cell carcinoma (ESCC)
Supervisor(s)

Professor ML Lung

Next Step?

For more information or to express interest to join the research areas, please email the supervisor or the specified contact point in the description. Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Research postgraduate studies enquiries specific to the department/school’s research should be directed to the Chairman of the Departmental Research Postgraduate Committee:

Professor XY Guan
xyguan@hku.hk

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.