Emergency Medicine Unit


Research Questions

  • What clinical and molecular markers improve the screening, prevention, detection, diagnosis, prognosis and treatment of infectious diseases and sepsis in the emergency department?
  • What are the underlying mechanisms of disease influencing the presence of these markers?
  • How could these markers guide the development of novel diagnostics, prognostics, vaccines and treatments?
Emergency Medicine Unit
Research Areas

1. Translational Studies and Mechanisms of Disease in Infectious Diseases and Sepsis

Our research programmes focus on understanding mechanisms of disease, molecular Omics and immunology of sepsis and infectious diseases. Our discoveries will lead to applications in molecular classification, screening, prevention, detection, diagnostics, prognostics and therapeutics.

We plan to perform comprehensive molecular profiling and integrative genomic and immunological studies on a large series of patients with infectious diseases and sepsis. We will develop and validate pathways using next-generation sequencing, expression microarray, methylation array and DNA SNP genotyping array. The discovery of novel biomarkers using slow, complex biotechnology may then be evaluated for rapid point of care tests.

This new initiative is seeking Theme-Based Research Scheme (TBRS) funding, angel investors as well as partnerships with major pharmaceutical and diagnostic companies.

Supervisor(s)

Professor T Rainer

Professor A Xu

 

2. Translational Studies and Mechanisms of Disease in Stroke

Our research programme focuses on early biomarker discoveries in Stroke in the emergency department. An understanding of the molecular Omics and immunology of stroke will lead to applications in molecular classification, screening, prevention, detection, diagnostics, prognostics and therapeutics.

Our team in Hong Kong will pioneer a translational programme focusing on the potential for circulating biomarkers as diagnostic and prognostic markers in patients with stroke.

We plan to perform comprehensive molecular profiling, integrative omics and immunological studies on patients with stroke and to develop and validate pathways using Omics approaches. The discovery of novel biomarkers using biotechnology may then be evaluated for rapid point of care tests.

Supervisor(s)

Professor T Rainer

Dr G Lau

 

3. Epidemiology, Prediction and Translational Studies in Acute Kidney Injury

Our research programme focuses on the underlying clinical and molecular epidemiology of acute kidney injury with the aim of developing pragmatic and clinically relevant prediction tools. Our team in Hong Kong will pioneer a translational programme focusing on the potential for circulating biomarkers as diagnostic and prognostic markers in patients with acute kidney injury. We plan to use our clinical and molecular discoveries to develop and validate diagnostic and prognostic tools in clinical practice.

Supervisor(s)

Professor T Rainer

Next Step?

For more information or to express interest to join the research areas, please email the supervisor or the specified contact point in the description. Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med] / RIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website.

General admission enquiries should be directed to rpgmed@hku.hk.