Research

Research Highlights


Cancer

Highlights

  • Developed an oral arsenic preparation to treat leukaemia, a first patented prescription drug developed entirely in Hong Kong
  • Identified and characterised cancer stem cells responsible for metastasis in colorectal cancer, and the development of liver cancer
  • Discovered a new mechanism causing Lynch Syndrome that has become a diagnostic test adopted worldwide
  • Hepatitis B virus infection and hepatocellular carcinoma: from diagnosis and treatment of chronic carrier status, mechanisms of hepatocellular carcinogenesis, to development of novel treatment modalities including live-donor liver transplantation
  • Comprehensive genomic study of gastric and liver cancers


UGC Area of Excellence

Project Coordinator: Prof Maria Li LUNG (2010)


UGC Theme-based Research Scheme

Project Coordinator: Prof Maria Li LUNG (2017)

Project Coordinator: Prof Irene Oi-lin NG (2016) 

Project Coordinator: Prof Suet-yi LEUNG (2016) 

 

Partner State Key Laboratory


Strategic Project

Cardiometabolic Diseases and Healthy Aging

Highlights

  • Leading research on adipokines and adipose-derived hormones
  • Research on metabolic diseases: identification of novel biomarkers for risk prediction and drug development in prevention and management of diabetes mellitus, obesity, cardiovascular diseases and thyrotoxic periodic paralysis


UGC Theme-based Research Scheme

Project Coordinator: Prof Hung-Fat TSE (2011)


Partner State Key Laboratory

Emerging Infectious Diseases

Highlights

  • Discovered the SARS coronavirus in 2003; pivotal in the fight against SARS
  • Human and animal (poultry, swine, wild birds) influenza viruses and other emerging viruses: from ecology, pathogen evolution, clinical presentation, innate immune responses, to drug development and prevention through national and global policy formulation and evaluation
  • Provided understanding on the evolutionary history, emergence and pathogenesis of the 2009 pandemic H1N1 virus; avian influenza viruses H5N1, H9N2 and H7N9; and MERS
  • Provided evidence-based options for the control of these viruses in poultry and in humans
  • Infectious disease epidemiology: insights into influenza transmission in the community; effectiveness and impact of control measures; modes of transmission of viruses; vaccination effectiveness; immunity to infections; mathematical models to assess the potential benefits and resource requirement of mitigation and surveillance strategies


UGC Area of Excellence

Project Coordinator: Prof Joseph Sriyal Malik PEIRIS (2008) 


UGC Theme-based Research Scheme

Project Coordinator: Prof Zhi-wei CHEN (2018)

Project Coordinator: Prof Patrick Chiu-yat WOO (2015)

Project Coordinator: Prof Joseph Sriyal Malik PEIRIS (2014)

 

State Key Laboratory


Collaborative Laboratories

Stem Cell, Development and Regenerative Biology

Highlights

  • Areas of focus include: basic and clinical stem cell biology, orthopaedic engineering, blood and cancer stem cells, stem cell immunology and bio-artificial tissue engineering
  • Working towards establishment of stem cells with totipotency features from mammalian species and characterisation of them using molecular and functional approaches including single cell genomics
  • Critical insights into the disease mechanisms of premature ageing, deafness, and digit development, through functional genomics and genetics
  • Generation of a mouse model for Brachydactyly type A1 by the TCF providing new insights into the development and formation of joints
  • Genetic and sequence analyses in the identification of a novel risk factor linked to degeneration of the spine and back pain

 

UGC Area of Excellence

Project Coordinator: Prof Kathryn S.E. CHEAH (2004)


UGC Theme-based Research Scheme

Project Coordinator: Prof Paul Kwong-hang TAM (2014) 

Project Coordinator: Prof Kathryn S.E. CHEAH (2012)


Collaborative Centre

Commitment to Global Health and Contribution to the Society
FAMILY: A Jockey Club Initiative for a Harmonious Society

To help build a more harmonious society, The Hong Kong Jockey Club Charities Trust has invited the School of Public Health of LKS Faculty of Medicine to collaboratively launch a project entitled “FAMILY: A Jockey Club Initiative for a Harmonious Society” with an initial funding of HK$250 million (2007-2014) and a follow-up funding of HK$50M (2014-2017). The project aims to identify the source of family problems, devise suitable preventive measures and promote family Health, Happiness and Harmony (3Hs) through a territory-wide household survey, intervention projects and public education.

Visit their website at: http://www.family.org.hk/ 


Jockey Club Early Psychosis (JCEP) Project (2008-2015)

The Hong Kong Jockey Club Charities Trust has supported the Department of Psychiatry of the LKS Faculty of Medicine to launch a 5-year Jockey Club Early Psychosis Project jointly with the Hospital Authority, Caritas Social Work Services and the Mental Health Association of Hong Kong. Awarded with HK$68.8M, the objectives of the project are: (1) Research – to evaluate the effectiveness and health economic implications of early intervention services for psychosis; (2) Education – to enhance public awareness of psychosis and to develop a trained network of professional gatekeepers skilled in the early detection of psychosis; (3) Service –early psychosis patients will receive intervention service and community-based group programmes provided by a specialized multidisciplinary team.

An educational website has been set up (www.jcep.hk), providing in-depth information about psychosis for the public, as well as news and developments of the project.