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A T cell resilience model associated with response to immunotherapy in multiple tumor types
Nature Medicine, 2022-07, Vol.28 (7), p.1421-1431
Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
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Jun 2022
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Lancet Microbe, 2022-06-01, Vol.3 (6), e404
Prenatal exposure to antidepressants or antipsychotics and the risk of seizure in children
World Psychiatry, 2022-06, Vol.21 (2), p.322-323
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Lancet Infectious Diseases, 2022-06-01, Vol.22 (6), p.750-751
May 2022
Modeling comparative cost-effectiveness of SARS-CoV-2 vaccine dose fractionation in India
Nature Medicine, 2022-05, Vol.28 (5), p.934-938
Severe influenza: is there a role for antiviral combinations?
Lancet Infectious Diseases, 2022-05-01, Vol.22 (5), p.574-576
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Apr 2022
Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019: a longitudinal study
Lancet Public Health, 2022-04-01, Vol.7 (4), e335-e346
Mar 2022
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Nature Medicine, 2022-03, Vol.28 (3), p.486-489
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Feb 2022
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New England Journal of Medicine, 2022-02-24, Vol.386 (8), p.801-803
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Nature Medicine, 2022-02, Vol.28 (2), p.239-240
Youth mental health care in a context of large-scale collective stress
World Psychiatry, 2022-02, Vol.21 (1), p.85-86
Jan 2022
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Dec 2021
Beyond immune checkpoint blockade: emerging immunological strategies
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Understanding longevity in Hong Kong: a comparative study with long-living, high-income countries
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Nov 2021
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Oct 2021
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial
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Sept 2021
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Lancet Microbe, 2021-09-01, Vol.2 (9), e423
Biological Gradient of Chronic Hepatitis B
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Effects of adjusting public health, travel, and social measures during the roll-out of COVID-19 vaccination: a modelling study
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Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis
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Aug 2021
Brief Advice, Nicotine Replacement Therapy Sampling, and Active Referral for Expectant Fathers Who Smoke Cigarettes: A Randomized Clinical Trial
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Jul 2021
Ethnicity Associations With Food Sensitization Are Mediated by Gut Microbiota Development in the First Year of Life
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May 2021
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TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation
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Apr 2021
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Mar 2021
Aspirin Use and Risk of Colorectal Cancer Among Older Adults
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Nature Medicine, 2021-03, Vol.27 (3), p.388-395
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Feb 2021
PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma
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Jan 2021
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Dec 2020
Evidence for action: a One Health learning platform on interventions to tackle antimicrobial resistance
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Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia
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Oct 2020
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Aug 2020
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Jul 2020
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Mar 2020
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Feb 2020
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Dec 2019
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Nov 2019
Upconversion-like Photolysis of BODIPY-Based Prodrugs via a One-Photon Process
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Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
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Jun 2019
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Injectable cell-encapsulating composite alginate-collagen platform with inducible termination switch for safer ocular drug delivery
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Identifying occult maternal malignancies from 1.93 million pregnant women undergoing noninvasive prenatal screening tests
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Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection
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Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank
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Dec 2018
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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening
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Chronic hepatitis B virus infection
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Oct 2018
Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases
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Jul 2018
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Association of an Early Intervention Service for Psychosis With Suicide Rate Among Patients With First-Episode Schizophrenia-Spectrum Disorders
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Mar 2018
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Jan 2018
Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study Free
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Characterizing the dynamics underlying global spread of epidemics
Nature Communications, January 2018, Volume 9, Article number: 218
Five-Year Effectiveness of the Multidisciplinary Risk Assessment and Management Programme–Diabetes Mellitus (RAMP-DM) on Diabetes-Related Complications and Health Service Uses—A Population-Based and Propensity-Matched Cohort Study
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Dec 2017
SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
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Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development
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Oct 2017
Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
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Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease
Nature Genetics, Volume 49, No. 12, Pages 1722-1730, October 2017
Sep 2017
Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies
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The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity
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Aug 2017
TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
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Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
Nature Neuroscience, Volume 20, No. 10, Pages 1342-1349, August 2017
Mar 2017
Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study
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Dec 2016
Fractional dosing of yellow fever vaccine to extend supply: a modelling study
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Oct 2016
Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia
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Aug 2016
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
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Jun 2016
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice
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Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin
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Mar 2016
Routine Pediatric Enterovirus 71 Vaccination in China: a Cost-Effectiveness Analysis
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Feb 2016
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Jan 2016
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Oct 2015
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Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice
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Impact of Secondhand Smoke Exposure on Smoking Cessation in Cardiac Patients
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Jun 2015
Dissemination, divergence and establishment of H7N9 influenza viruses in China
Nature, Volume 522, Issue 7554, 102–105, 04 June 2015.
May 2015
Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
Circulation, 2015 May 26;131(21):1861-71.
Apr 2015
One More “C” for CHA2DS2-VASc Score?
Journal of the American College of Cardiology, Volume 65, Issue 15, Pages 1602-1603, 21 April 2015.
Oct 2013
The genesis and source of the H7N9 influenza viruses causing human infections in China
Nature, 502 (7470) : 241–244, October 2013
Sept 2013
Prognostic Value of Preoperative Right Ventricular Geometry and Tricuspid Valve Tethering Area in Patients Undergoing Tricuspid Annuloplasty
Circulation, September 2013 (online published).
Aug 2013
Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study.
Circulation, 128 (7) : 687-93, August 2013.
Reducing Treatment Decision Conflict Difficulties in Breast Cancer Surgery: A Randomized Controlled Trial
Journal of Clinical Oncology, 31 (23) : 2879-2885, August 2013.
Jul 2013
Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases
The Lancet, 382 (9887), 129 - 137, July 2013.
Human infection with avian influenza A H7N9 virus: an assessment of clinical severity
The Lancet, 382 (9887) : 138–145, July 2013.
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs.
Science. Vol. 341, Issue 6142, pp. 183-186, 12 Jul 2013.
Jun 2013
Association between adverse clinical outcome in human disease caused by novel infl uenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance
The Lancet, 381 (9885) : 2273–2279, June 2013.
Detection of mild to moderate influenza A/H7N9 infection by China’s national sentinel surveillance system for influenza-like illness: case series
British Medical Journal, 346 : 3693, June 2013.
Apr 2013
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Nature, 496 (7443) : 110–113, April 2013.
Feb 2013
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
Nature Medicine, 19 (2) : 209 - 216, February 2013
Nov 2011
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Science, 334 (6057) : 806-809, November 2011
Oct 2011
Estimating Infection Attack Rates and Severity in Real Time during an Influenza Pandemic: Analysis of Serial Cross-Sectional Serologic Surveillance Data
PLoS Medicine, 8 (10): e1001103, October 2011.
Sequential Establishment of Stripe Patterns in an Expanding Cell Population
Science, 334 (6053) : 238-241, October 2011
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
Nature Genet, 43 (12) : 1219-23, Oct 2011
Sep 2011
Human Sperm Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida
Science, 333 (6050) : 1761-1764, September 2011.
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.
J Clin Invest, Volume 121, Issue 9 : 3467-78, September 1, 2011.
Jun 2011
CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation
Cell Stem Cell, 9 (1) : 50–63, July 2011.
Epidemiological Characteristics of 2009 (H1N1) Pandemic Influenza Based on Paired Sera from a Longitudinal Community Cohort Study
PLoS Medicine, 8 (6): e1000442, June 2011.
Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score
The Lancet Oncology, 12 (6): 568-574, June 2011.
May 2011
Long-term evolution and transmission dynamics of swine influenza A virus
Nature, 473 (7348) : 519–522, May 2011
Dec 2010
miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1
Cell Stem Cell, 7 : 6, 694-707, December 2010
A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects
Cell Stem Cell, 8 (1): 31-45, December 2010.
Oct 2010
SOX9 induces and maintains neural stem cells
Nature Neuroscience, 13 (10) : 1181–1189, October 2010
Aug 2010
Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial
British Medical Journal, 341 : 4024, August 2010
Effect of an Advocacy Intervention on Mental Health in Chinese Women Survivors of Intimate Partner Violence: A Randomized Controlled Trial
Journal of the American Medical Association, 304 : 5, 536-543, August 2010
Jun 2010
Identification of influenza A nucleoprotein as an antiviral target
Nature Biotechnology, 28 : 6, 600–605, June 2010
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
Science, 328, 1529, June 2010
A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
Cell Stem Cell, 6 : 6, 603-615, June 2010
Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households
The New England Journal Medicine, 362 : 2175-2184, June 2010
Mar 2010
Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice
Circulation, 121 (9):1113-1123, March 2010
Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1
Molecular Cell 37 (6) : 854–864, March 2010
Dec 2007
Telbivudine versus Lamivudine in Patients with Chronic Hepatitis B
The New England Journal of Medicine. 357 : 25, :2576 - 88, 20 December 2007.
Oct 2007
Protein arginine-methyltransferase-dependent oncogenesis
Nature Cell Biology, v. 9, (10), p. 1208-31215, October 2007.
Treatment with Convalescent Plasma for Influenza A (H5N1) Infection
The New England Journal of Medicine, 357 : 14, 1450-1451, October 4, 2007.
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
Nature Medicine, 13 : 10, 1228-1233, October 2007.
Apr 2007
Omeprazole before Endoscopy in Patients with Gastrointestinal Bleeding
The New England Journal of Medicine, 356 : 16, 1631-1640, April 2007.
Mar 2007
Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome: A 5-Year Prospective Study
Circulation, Volume 115, Issue 12, p.1537-1543, March 27, 2007.
Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study.
The Lancet, 369: 9566, 993-999, March 2007
Feb 2007
Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract.
Nature Medicine, 13 : 2, 147-149, February 2007.
Nov 2006
Effect of obesity in patients with coronary artery disease
The Lancet, 368 : 9548, 1645-1645, November 2006
Oct 2006
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
Nature Genetics, 38 : 10, 1178-1183, October 2006
Sep 2006
Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model
Circulation, Volume 114, Issue 10, p.1000-11, September 5, 2006.
Reducing the impact of the next influenza pandemic using household-based public health interventions
PLoS Medicine, Volume 3, Issue 9, p.1532-1540, September 2006.
Jul 2006
The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication
Nature Cell Biology, 8, 717 – 724, July 2006
Apr 2006
Influenza-Associated Hospitalization in a Subtropical City
PLoS Medicine, Volume 3, Issue 4, p.485-492, April 2006.
Mar 2006
Cytotoxic therapy for severe avian influenza A (H5N1) infection
The Lancet, 367 : 9513, 870-873, March 2006
Entecavir versus Lamivudine for Patients with HBeAg-Negative Chronic Hepatitis B
The New England Journal of Medicine, 354 : 10, 1011-1020, March 2006
Feb 2006
Clozapine Alone versus Clozapine and Risperidone with Refractory Schizophrenia
The New England Journal of Medicine,. 354 : 5, p. 472-482, February 2006.
White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function
Journal of Clinical Oncology, v.24, (6), p,884-890, February 2006.
Jan 2006
Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
Nature Genetics, 38 : 1, 38-46, January 2006
Aug 2005
H5N1 influenza pandemic: contingency plans
The Lancet, 366 : 9485, 533-534, August 2005
Jul 2005
Avian flu: H5N1 virus outbreak in migratory waterfowl
Nature, 436 : 191-192, July 2005
Genomic instability in laminopathy-based premature aging
Nature Medicine, 11 : 7, 780-785, July 2005
Jun 2005
Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B
The New England Journal of Medicine, 352 : 26, 2682-2695, June 2005
Apr 2005
Sox2 is required for sensory organ development in the mammalian inner ear
Nature, 434 : 1031-1035, April 2005
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
Proc Natl Acad Sci, 102 : 17, 6086-6091, April 2005
Dec 2004
Severe acute respiratory syndrome
Nature Medicine, 10 : 12, S88-S97, December 2004
Jul 2004
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
Nature, 430 : 209-213, July 2004
Jun 2004
Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case-control study
The Lancet, 363 : 1941-47, June 2004
Jan 2004
Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China
Journal of the American Medical Association, 291 : 2, 187-194, January 2004
Oct 2003
Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China
Science, 302 : 5643, 276-278, October 2003
Jul 2003
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
Journal of Clinical Investigation, 112 : 1, 91-100, July 2003
Jun 2003
Transmission Dynamics of the Etiological Agent of SARS in Hong Kong: Impact of Public Health Interventions
Science, 300 : 5627, 1961-1966, June 2003
May 2003
Development of a standard treatment protocol for severe acute respiratory syndrome
The Lancet, 361 : 9369, 1615-1617, May 2003
Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study
The Lancet, 361 : 9371, 1767-1772, May 2003
Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS)
The Lancet, 361 : 9368, 1519-1520, May 2003
Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong
The Lancet, 361 : 9371, 1761-1766, May 2003
Lung pathology of fatal severe acute respiratory syndrome
The Lancet, 361 : 9371, 1773-1778, May 2003
A Cluster of Cases of Severe Acute Respiratory Syndrome in Hong Kong
The New England Journal of Medicine, 348 : 20, 1977-1985, May 2003
Apr 2003
Coronavirus as a possible cause of severe acute respiratory syndrome
The Lancet, 361 : 9366, 1319-1325, April 2003
Jan 2003
Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
The Lancet, 361 : 9351, 47-49, January 2003
Dec 2002
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
The Lancet, 360 : 9348, 1831-1837, December 2002
Influenza-related hospitalizations among children in Hong Kong
The New England Journal of Medicine, 347 : 26, 2097-2103, December 2002
Nov 2002
Cardiorespiratory and all-cause mortality after restrictions on sulphur content of fuel in Hong Kong: an intervention study
The Lancet, 360 : 9346, 1646-1652, November 2002
Jun 2002
A Genetic Locus for Adolescent Idiopathic Scoliosis Linked to Chromosome 19p13.3
American Journal of Human Genetics, 71 : 401-406, June 2002
Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR
Proc Natl Acad Sci, 99 : 13, 8950-8955, June 2002
Lansoprazole for the Prevention of Recurrences of Ulcer Complications from Long-Term Low- Dose Aspirin Use
The New England Journal of Medicine, 346 : 26, 2033-2038, June 2002
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