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research description

My research interests focus on T cell responses in anti-viral immunity and HIV infection in T cells. For T cell responses in anti-viral immunity, I aim at understanding immunometabolic regulation in T cell responses against HIV/AIDS and SARS-CoV-2/COVID-19. For HIV infection in T cells, I aim at understanding the effect of metabolic regulation on HIV infection in CD4 T cells. The goal of my study is to identify potential therapeutic methods, in terms of metabolic regulation, for promoting anti-viral immunity in infectious diseases.

selected Publication

First/Co-First author publications

Mo Y, To KK, Zhou R, Liu L, Cao T, Huang H, Du Z, Lim CYH, Yim LY, Luk TY, Chan JM, Chik TS, Lau DP, Tsang OT, Tam AR, Hung IF, Yuen KY, Chen Z. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Front Immunol. 2022 Jan 14;12:799896. doi: 10.3389/fimmu.2021.799896 (Co-first author)

Mo Y, Cheung AKL, Liu Y, Liu L, Chen Z. Imaging and analysis on the interaction between human antigen-pulsed Vδ2 T cells and antigen-specific CD4 T cells. STAR Protoc. 2021 Apr 14;2(2):100453. doi:10.1016/j.xpro.202 1.100453. (Co-first author)

Mo Y, Cheung AKL, Liu Y, Liu L, Chen Z. Δ42PD1-TLR4 Augments γδ-T Cell Activation of the Transitional Memory Subset of CD4+ T Cells. iScience. 2020 Sep 28;23(10):101620. doi: 10.1016/j.isci.2020.101620. (Co-first author)

Co-author Publication

Cao T, Liu L, To KK, Lim CY, Zhou R, Ming Y, Kwan KY, Yu S, Chan CY, Zhou B, Huang H, Mo Y, Du Z, Gong R, Yat LT, Hung IF, Tam AR, To WK, Leung WS, Chik TS, Tsang OT, Lin X, Song YQ, Yuen KY, Chen Z. Mitochondrial regulation of acute extrafollicular B-cell responses to COVID-19 severity. Clin Transl Med. 2022 Sep;12(9):e1025. doi: 10.1002/ctm2.1025. PMID: 36103567

Zhou R, To KK, Wong YC, Liu L, Zhou B, Li X, Huang H, Mo Y, Luk TY, Lau TT, Yeung P, Chan WM, Wu AK, Lung KC, Tsang OT, Leung WS, Hung IF, Yuen KY, Chen Z. Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses. Immunity. 2020 Oct 13;53(4):864-877.e5. doi: 10.1016/j.immuni.2020.07.026.

Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF, Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35): eaba7910. doi: 10.1126/sciadv.aba7910.

Cheung AKL, Kwok HY, Huang Y, Chen M, Mo Y, Wu X, Lam KS, Kong HK, Lau TCK, Zhou J, Li J, Cheng L, Kiat Lee B, Peng Q, Lu X, An M, Wang H, Shang H, Zhou B, Wu H, Xu A, Yuen KY, Chen Z. Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection. Nat Microbiol. 2017 Oct;2(10):1389- 1402. doi: 10.1038/s41564-017-0006-5

Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M, Bi H. Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta Pharm Sin B. 2017 Sep;7(5):583-592. doi: 10.1016/j.apsb.2017.04.002.

Deng Y, Mo YF, Chen XM, Zhang LZ, Liao CF, Song Y, Xu C. Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats. Phytother Res. 2016 Nov;30(11):1886-1892. doi: 10.1002/ptr.5691.