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research description

My research focuses on the development of a human tonsil organoid from tissue samples. This approach allows recapitulation of human immunity in response to in vivo pathogenic infections. Hence, my research interest is extended to using this organoid as an HIV-1 infection study model. In parallel, I am also interested in profiling HIV-infected myeloid-derived suppressor cells (MDSCs) and targeting this cell population for a more effective therapeutic against HIV-1 infection.

selected Publication

Yip, CH, Mahalingam, S, Wan, KL & Nathan, S. 2021. Prodigiosin inhibits bacterial growth and virulence factors as a potential physiological response to interspecies competition. PLOS ONE 16(6): e0253445.

Yip, CH, Ahmad-Kamal, G & Nathan, S. 2020. Burkholderia pseudomallei pathogenesis and survival in different niches. Biochemical Society Transactions 48(2): 1-11.

Yip, CH, Yarkoni, O, Juhas, M, Ajioka, J, Wan, KL & Nathan, S. 2019. The Escherichia coli motA flagellar gene as a potential integration site for large synthetic DNA. Sains Malaysiana 48(1): 81-91.

Yip, CH, Yarkoni, O, Ajioka, J, Wan, KL & Nathan, S. 2019. Recent advancements in the high-level synthesis of the promising clinical drug, prodigiosin. Applied Microbiology and Biotechnology.

Yip, CH, Yarkoni, O, Ajioka, J, Wan, KL & Nathan, S. 2018. Development of a codon optimization strategy using the efor RED reporter gene as a test case. American Institute of Physics Conference Proceedings 1940(1):020080.