Tel: + 852 39179825 Fax: +852 39179095

Contact us

research description

The period preceding, during, and afterwards the occurrence of a disease is analogous to a crime scene. My research interest is to play as a detective, using biological data and informatics technologies to reconstruct the crime process, track the source, and identify the "culprit" who caused the disease.

selected Publication

First/Co-First author publications

Yue M,Zhou D, Zhi H, Wang P, Zhang Y, Gao Y, Guo M, Li X, Wang Y, Zhang Y, Ning S, Li X. MSDD: a manually curated database of experimentally supported associations among miRNAs, SNPs and human diseases.Nucleic Acids Res. 2018 Jan 4;46(D1):D181-D185..

Co-author Publication

Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z. SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1. Emerg Microbes Infect 2023 Dec;12(2):2245921.

Li S, Poon CH, Zhang Z, Yue M, Chen R, Zhang Y, Hossain MF, Pan Y, Zhao J, Rong L, Chu LW, Shea YF, Rogaeva E, Tu J, St George-Hyslop P, Lim LW, Song YQ. MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3 , APPBP2, and mTOR in Alzheimer's disease. CNS Neurosci Ther. 2023 Mar 7.

Tan Z, Chiu MS, Yang X,Yue M, Cheung TT, Zhou D, Wang Y, Chan AW, Yan CW, Kwan KY, Wong YC, Li X, Zhou J, To KF, Zhu J, Lo CM, Cheng AS, Chan SL, Liu L, Song YQ, Man K, Chen Z. Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients. Gut.2022 Nov 30:gutjnl-2022-327133.

Cao T, Liu L, To KK, Lim CY, Zhou R, Yue M, Kwan KY, Yu S, Chan CY, Zhou B, Huang H, Mo Y, Du Z, Gong R, Yat LT, Hung IF, Tam AR, To WK, Leung WS, Chik TS, Tsang OT, Lin X, Song YQ, Yuen KY, Chen Z. Mitochondrial regulation of acute extrafollicular B-cell responses to COVID-19 severity. Clin Transl Med. 2022 Sep;12(9):e1025.

Zhang BZ, Shuai H, Gong HR, Hu JC, Yan B, Yuen TT, Hu YF, Yoon C, Wang XL, Hou Y, Lin X, Huang X, Li R, Au-Yeung YM, Li W, Hu B, Chai Y, Yue M, Cai JP, Ling GS, Hung IF, Yuen KY, Chan JF, Huang JD, Chu H. Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice.JCI Insight. 2022 Jun 8;7(11):e157393.

Zhang Y, Zhang Y, Aman Y, Ng CT, Chau WH, Zhang Z,Yue M, Bohm C, Jia Y, Li S, Yuan Q, Griffin J, Chiu K, Wong DSM, Wang B, Jin D, Rogaeva E, Fraser PE, Fang EF, St George-Hyslop P, Song YQ. Amyloid-  toxicity modulates tau phosphorylation through the PAX6 signalling pathway.Brain. 2021 Oct 22;144(9):2759-2770.

Wong YC, Liu W, Yim LY, Li X, Wang H, Yue M, Niu M, Cheng L, Ling L, Du Y, Chen SMY, Cheung KW, Wang H, Tang X, Tang J, Zhang H, Song Y, Chakrabarti LA, Chen Z. Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination. PLoS Pathog. 2021 Jun 14;17(6):e1009647.

Zhi H, Li X, Wang P, Gao Y, Gao B, Zhou D, Zhang Y, Guo M, Yue M, Shen W, Ning S, Jin L, Li X. Lnc2Meth: a manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease. Nucleic Acids Res.2018 Jan 4;46(D1):D133-D138.

Ning S, Yue M,Wang P, Liu Y, Zhi H, Zhang Y, Zhang J, Gao Y, Guo M, Zhou D, Li X, Li X. LincSNP 2.0: an updated database for linking disease-associated SNPs to human long non-coding RNAs and their TFBSs. Nucleic Acids Res. 2017 Jan 4;45(D1):D74-D78.

Ning S, Zhang J, Wang P, Zhi H, Wang J, Liu Y, Gao Y, Guo M,Yue M,Wang L, Li X. Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers. Nucleic Acids Res. 2016 Jan 4;44(D1):D980-5.