Activities > lectures and Seminars > 2012
No. Date Name of Speaker Affiliation Title
Title Given name Surname
1 Jan 9, 2012 The 8th Clinical Genetics Round 　 　
　 　 Dr Brian Hon-Yin Chung Clinical Associate Professor
Department of Paediatrics & Adolescent Medcine; Department of Obstetrics & Gynaecology		 The Shifting sands of orofacial clefting
　 　 Dr Tiong-Yang Tan Clinical Assistant Professor
Department of Biochemistry; Department of Paediatrics & Adolescent Medcine
2 Jan 17, 2012 AoE Symposium on Developmental Genomics and Genetics Disorders　　　 　
　 　 Prof
Sir 		 Walter Bodmer Oxford University, UK Genetics and biology of colorectal cancer: Cell lines and stem cells
　 　 Dr Jian-dong  Huang The University of Hong Kong Kinesin-1 is important for cytokinesis in chondrocytes
　 　 Prof Xue Zhang Chinese Academy of Medical Sciences & Peking Union Medical College Genetic study of X-linked congenital hypertrichosis syndrome
　 　 Prof Kathryn Cheah The University of Hong Kong How chondrocytes survive endoplasmic reticulum stress  - implications for congenital skeletal disorders
　 　 Prof Henry  Kronenbery Harvard University, USA How PTHrP regulates chondrocyte differentiation
　 　 Prof Shiro Ikegawa SNP Research Center, RIKEN, Japan Next steps for genetic study of skeletal diseases- problems and solutions from 10 years’  experience
　 　 Dr

Prof		 Danny

Kenneth		 Chan

Cheung
 The University of Hong Kong Lessons learnt from Hong Kong Degenerative Disc Cohort: clinical and genetic findings
　 　 Prof Allan Bradley Wellcome Wellcome Trust Sanger Institute, UK Genetics in stem cells: From gene discovery to therapy
　 　 Prof Bjorn Olsen Harvard University, USA Endothelial cells and vascular endothelial growth factor in formation and maintenance of bone
3 Mar 25 - 28, 2012 The 3rd Symposium on Development of the Enteric Nervous System 　
　 Mar 25, 2012 　 Vassilis Pachnis MRC National Institute for Medical Research, London, UK Putting some sENSe into the gut: From neural crest stem cells to functional neuronal circuits 
　 Mar 26. 2012 　 Marianne Bronner California Institute of Technology, CA, USA Gene regulatory network underlying neural crest development 
　 　 　 Roberto Mayor  University College London, London, UK Collective migration of neural crest cells: a balance of repulsion and attraction 
　 　 　 Woody  Chan The Chinese University of Hong Kong, Hong Kong, China Sacral neural crest: A distinct population of migratory cells contributing to the hindgut enteric nervous system in the mouse embryo 
　 　 　 Alan Burns  UCL Institute of Child Health, London, UK Lack of organ specific commitment of vagal neural crest cells as shown by back-transplantation of transgenic GFP chicken tissues 
　 　 　 Jie-Lin Chen  The Chinese University of Hong Kong, Hong Kong, China Migratory behaviours of sacral neural crest cells in the hindgut of mouse embryos as shown by live cell imaging 
　 　 　 Amanda Barlow University of Toledo, Toledo, USA Continued advancement of neural crest cells along the gut at late developmental stages in Tcof1 Haploinsufficient mice (SDB Travel Award) 
　 　 　 Mai Har Sham  The University of Hong Kong, Hong Kong, China Sox10NGFP mutation affects migration of enteric neural crest cells in mouse embryonic gut 
　 　 　 Michelle Southard-Smith Vanderbilt University Medical Center, Nashville, USA Combining genetic approaches with RNASeq to identify differentially expressed genes in modifier intervals of the Sox10Dom Hirschsprung model 
　 　 　 Ulrika Marklund  Karolinska Institute, Stockholm, Sweden Specification of neuronal subtypes in the developing enteric nervous system 
　 　 　 Julia Ganz  University of Oregon Institute of Neuroscience, Eugene, USA Genetic and microbial influences on zebrafish enteric nervous system development and function 
　 　 　 Iain Shepherd  Emory University, Atlanta, Georgia, USA Proliferate or Differentiate? Insights into the role of BMP signalling in zebrafish ENS development 
　 　 　 Tiffany Heanue MRC National Institute for Medical Research, London, UK Zebrafish ret mutants as HSCR model and screening tool 
　 　 　 Leen Uyttebroek Universiteit Antwerpen, Antwerp, Belgium The zebrafish mutant, lessen: a valuable experimental model to study Hirschsprung’s disease 
　 　 　 Allan Goldstein  Harvard Medical School, Boston, USA The cecal region: ENS gateway into the colorectum 
　 　 　 Raj Kapur Seattle Children’s Hospital and University of Washington, Seattle, USA Innervation anomalies in the transition zone of Hirschsprung disease 
　 　 　 Hideki Enomoto RIKEN Center for Developmental Biology, Kobe, Japan Non-polyalanine repeat expansion mutations of the PHOX2B gene dysregulate Sox10 expression and cause neurocristopathy in the autonomic nervous system in mice 
　 　 　 Ankush Gosain  University of Wisconsin, Madison, WI, USA Impaired gastrointestinal mucosal immunity in the neural crest-specific deletion of endothelin receptor-B model of Hirschsprung’s disease 
　 　 　 Elizabeth C Wright-Jin  Washington University School of Medicine, St. Louis, Missouri, USA Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction 
　 Mar 27, 2012 　 Robert Heuckeroth Washington University School of Medicine, St. Louis, USA Gene environment interactions that influence enteric nervous system development: Hope for disease prevention 
　 　 　 Sylvie Dufour UMR - Institut Curie – CNRS, Paris, France Interplays between N-cadherin and β1-integrins during the development of the enteric nervous system 
　 　 　 Nadege Bondurand  INSERM U955, IMRB, Creteil, France Genetic interaction between Sox10 and β1 integrins during enteric nervous system development 
　 　 　 Don Newgreen Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Australia Differential cell adhesion governs gangliogenesis in the enteric nervous system 
　 　 　 Jonathan I Lake Washington University School of Medicine, St. Louis, Missouri, USA The de novo guanine nucleotide synthesis inhibitor mycophenolic acid impairs enteric nervous system development in vivo and in vitro 
　 　 　 Kenneth N Wallace Clarkson University, Potsdam, NY, USA Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of posterior intestinal motility 
　 　 　 Michael Gershon Columbia University, New York, USA Transmitter signaling in enteric neuronal development: catecholamines and serotonin 
　 　 　 Marthe Howard  University of Toledo, Toledo, USA Hand2 functions in neurogenesis, neurotransmitter identity and gangliogenesis in the developing mouse ENS 
　 　 　 Heather Young University of Melbourne, Melbourne, Australia The spatial order and behavior of neural crest-derived cells as they colonize the mouse gut 
　 　 　 Elly SW  Ngan  The University of Hong Kong, Hong Kong, China Hedgehog-Notch induced premature gliogenesis: a new disease mechanism for Hirschsprung’s disease 
　 　 　 Paola Griseri Institute G.Gaslini, Genoa, Italy Involvement of the RET/GDNF signalling in the immune response and implications for the development of Hirschsprung-Associated Enterocolitis 
　 　 　 Valentina Sasselli  MRC National Institute for Medical Research, London, UK Role of the planar cell polarity signalling pathway in the wiring of the enteric nervous system (SDB Junior Scientist Travel Award) 
　 Mar 28, 2012 　 Aravinda Chakravarti Johns Hopkins University School of Medicine, Baltimore, USA Is Hirschsprung disease genetic? 
　 　 　 Robert Hofstra University of Groningen, Groningen, The Netherlands Genetic dissection and functional studies in Hirschsprung diseases 
　 　 　 Isabella Ceccherini Istituto Giannina Gaslini, Genova, Italy CNVs analysis in Hirschsprung disease 
　 　 　 Jeanne Amiel Hopital Necker-Enfants Malades, Paris, France Hirschsprung disease illustrates a multifactorial mechanism of parent-of-origin effect in complex genetic diseases 
　 　 　 Paul  Tam The University of Hong Kong, Hong Kong, China Neuregulins and Hirschsprung disease 
　 　 　 Clara Tang  The University of Hong Kong, Hong Kong, China Meta-analysis of genome-wide association studies in Hirschsprung disease patient populations of European and Asian ancestry (on behalf of the HSCR Consortium) 
　 　 　 Joel Bornstein  University of Melbourne, Melbourne, Australia Enteric involvement in neuropsychiatric diseases: lessons from the NL3 mouse model of autism 
　 　 　 Pieter Vanden Berghe LENS, KULeuven, Leuven, Belgium Imaging neuronal activity in the ENS from development to disease 
　 　 　 Marlene Hao University of Melbourne, Melbourne, Australia Early development of electrical activity during the development of the enteric nervous system 
　 　 　 Anne Schuster University of Applied Sciences, Kaiserslautern, Germany Lipopolysaccharide induces cell responses in myenteric neurons by effecting L-type voltage gated calcium channels 
　 　 　 Jaime Pei-Pei  Foong University of Melbourne, Melbourne, Australia Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development 
　 　 　 Ryo Hotta  University of Melbourne, Melbourne, Australia Enteric neural stem/progenitor cells grafted into the post-natal colon generate neurons with appropriate neurochemical, morphological and electrophysiological properties 
　 　 　 Nikhil Thapar UCL Institute of Child Health and Great Ormond Street Hospital, London, UK Practical steps in establishing enteric neural stem cell therapies 
　 　 　 Julie E Cooper  UCL, Institute of Child Health, London, UK Enteric neural stem cell labelling and in vivo transplantation into mouse gut 
　 　 　 David Wilkinson University of Liverpool, Liverpool, UK Enteric nervous system progenitor cell proliferation and differentiation in the neurosphere niche 
　 　 　 Naoki Shimojima Keio University School of Medicine, Department of Pediatric Surgery, Tokyo, Japan Isolation, proliferation, and differentiation of neural crest stem/progenitor cells from human gut in normal and motility disorder patients 
4 Mar 31, 2012 Symposium on Recent Advances in Autism: Clinical and Scientific Aspects 　 　 　 　
　 　 Prof Wendy Roberts Hospital for Sick Children, University of Toronto Intervention prior to Diagnosis: Changing Perspectives in Autism

Ethical and Clinical Dilemmas in expanded Genetic Evaluation of Individuals with Autism  
　 　 Prof Ching-Wan Lam Centre for Reproduction, Development & Growth and Department of Pathology, The University of Hong Kong    Recent  Advances in the Genetic Basis of Autism 
　 　 Dr Brian Chung Centre for Reproduction, Development  & Growth, Departments of Obstetrics & Gynaecology  and  Paediatrics & Adolescent Medicine, The University of Hong Kong  Evaluation of Children with Autism Spectrum Disorder – A Clinical Geneticist’s Perspective 
　 　 Dr Charlton Cheung Department of Psychiatry, The University of Hong Kong  Neuroimaging in Autism Spectrum Disorder 
　 　 Dr Cheuk-Wing Fung Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital   Autism: A Treatment Perspective 
5 Apr 1, 2012 Prof Wendy Roberts Hospital for Sick Children, University of Toronto MiniADOS Workshop - Diagnosis of Autism Spectrum Disorder using
an Office-Based Physical Examination
6 Apr 10, 2012 Prof Lee-Jun C Wong Department of Molecular and Human Genetics;
Director, Mitochondrial Diagnostic Laboratory
 Next Generation Sequencing: Translation to Clinical Diagnostics
7 Apr 16, 2012 The 9th Clinical Genetics Round 　 　
　 　 Dr Anthony Pak-Yin Liu Clinical Associate Professor
Department of Paediatrics & Adolescent Medcine		 Paediatric Inherited Arrhythmias - an interdisciplinary approach
　 　 Dr Brian Hon-Yin Chung Clinical Associate Professor
Department of Paediatrics & Adolescent Medcine; Department of Obstetrics & Gynaecology		 　
　 　 Dr Tiong-Yang Tan Clinical Assistant Professor
Department of Biochemistry; Department of Paediatrics & Adolescent Medcine		 　
8 May 3, 2012 Prof Blanche Capel Department of Cell Biology,Duke University, USA
 The Battle of the Sexes: Exploring the Transcriptional Architecture Underlying Sex Determination
9 May 14, 2012 Dr Myriam  Hemberger Group Leader, The Babraham Institute, UK DNA Methylation Hallmarks Define Stem Cells of the Early Embryo
　 　 Dr  Wendy Dean Senior Research Scientist, The Babraham Institute, UK
 Resetting the Methylome in Mouse
Primordial Germ Cells
10 May 17, 2012 Sub Theme Seminar: Genetics of Disorders and Developmental & Functional Genomics
　 　 Prof Ching-Wan Lam Department of Pathology, The University of Hong Kong Clinical Biomonitoring of Environmental Chemicals
　 　 Dr Danny Chan Department of Biochemistry, The University of Hong Kong Research in rare diseases: a personal journey
11 June 27, 2012 Sub-Theme seminar: Stem Cells in Developmental Biology and Regenerative Medicine
　 　 Dr Anskar YH Leung Department of Medicine, The University of Hong Kong Blood Development in Zebrafish Embryos – a Leukemia Perspective
　 　 Dr Jianbo Yue Department of Physiology, The University of Hong Kong Calcium, Stem cells, Autophagy, and, …..
12 June 29, 2012 Dr Bernd Fritzsch Department Head,Department of Biology, College of Liberal Arts and Sciences, University of Iowa, USA The Molecular Basis of Neurosensory Development of the ear: Do we understand enough to initiate repairs?
13 July 6, 2012 Prof Quan  Chen The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences & College of Life Sciences, Nankai University, China

 Molecular signaling towards mitochondrial autophagy
14 July 9, 2012 The 10th Clinical Genetics Round 　 　
　 　 Dr Brian Hon-Yin Chung Clinical Associate Professor
Department of Paediatrics & Adolescent Medcine
Department of Obstetrics & Gynaecology		 Should we make preimplantation genetic diagnosis more accessible?”: Potential benefits & ethical issues of insurance coverage on PGD
　 　 Ms Yoyo Chung Student in Master of Genetic Counselling, University of Melbourne, Australia
 　
15 July 23, 2012 The 11th Clinical Genetics Round 　 　
　 　 Dr Alan WL Fung Co-Director, The Dalglish Hearts & Minds Clinic for 22q11.2 Deletion Syndrome, Toronto General Hospital, University Health Network 22q11.2 deletion syndrome - the quintessential multisystem genomic disorder
16 July 31, 2012 Prof Mari Dezawa Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology
Tohoku University Graduate School of Medicine, Sendai, Japan
Muse cells, a novel type of adult human pluripotent stem cells that reside in mesenchymal tissues: their great possibility for regenerative medicine and tissue repair
17 Agu 28, 2012 Sub-Theme seminar: Reproduction sub-theme 　
　 　 Dr WS O Dept of Anatomy Adrenomedullin as a biomarker for tubal ectopal pregnancy - new evidence from adrenomedullin function in the nasal ciliary epithelium
　 　 Dr CKF Lee Dept of Obstetrics & Gynaecology The use of co-culture models to study embryo implantation process
18 Sept 3, 2012 Prof Urban  Lendahl Professor of Genetics, Department of Cell and Molecular Biology, Karolinska Institute
 Notch Signaling in Development and Disease
19 Sept 18, 2012 Sub Theme Seminar: Genetics of Disorders and Developmental & Functional Genomics
　 Dr Yvonne Ka Yin Kwok  Scientific Officer, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong  Bead-based Assay: A New Paradigm for Prenatal Diagnosis 
　 　 Dr Richard Kwong Wai  Choy Associate Professor, Department of Obstetrics and Gynaecology , The Chinese University of Hong Kong  The story of Fetal DNA Chip 
20 Oct 15, 2012 Prof Jean Paul Thiery Professor and Head, Department of Biochemistry, National University of Singapore Adhesion mechanisms; implication for EMT
21 Oct 26, 2012 Prof Han-Ming Shen Dept of Physiology, Yong Loo Lin School of Medicine
National University of Singapore		 Regulation of lysosomal function in the course of autophagy
22 Nov 23, 2012 Dr Christopher J Marx Associate Profesor of Biology, Harvard University Using metabolic models and experimental evolution to explore epistasis, optimality and tradeoffs during adaption
23 Nov 23, 2012 Prof Chi-Chung Hui Professor of Molecuar Genetics, University of Toronto The yin-yan of Hedgehog signalling
24 Nov 26 - 27, 2012 Hong Kong Society for Developmental Biology Symposium – From Embryology to Disease Mechanisms
25 Dec 14, 2012 Frontiers in Biomedical Research 　 　 　 　
　 Cancelled- Nobel Prize winnder Prof
Sir 		 John Gurdon University of Cambridge Nuclear Reprogramming by Eggs and Oocytes: A Potential Route towards Cell Replacement Therapy
　 　 Prof Reinhard  Faessler Max Planck Institute of Biochemistry, Germany  How Cells Control the Integrity of Integrins
　 　 Prof Stephen Quake Stanford University Is the Genome Useful in Medicine?
26 Dec 17, 2012 Prof Robin Lovell-Badge Distinguished Visiting Professor, HKU and Head, Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK Homeostasis and Life-changing events: Stem Cells, regeneration and plasticity in the pituitary-hypothalamic axis
27 Dec 19, 2012 Prof Gen Yamada Department of Organ Formation, The Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Japan Growth Factor Cascade for Reproductive Organ Formation: Toward the Molecular Mechanisms for Sexual Differentiation


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