HIV-infected patients receiving antiretroviral therapy (ART) experience viremia rebound shortly after treatment cessation. This indicates viral persistence in infected cells and has remained the major hurdle in complete HIV cure. Although the transcriptome of infected cell changes upon infection, no reliable HIV latency markers has been discovered so far. My research focuses on understanding HIV latency in T cells, aiming to distinguish T cell populations that serves as potent HIV reservoirs during chronic HIV infection. The goal of my study is to identify possible targets for complete viral eradication via delineating the mechanisms in establishing and maintaining HIV latency.
Sheng Yan, Lok Yan Yim, Rachel Chun Yee Tam, Albert Chan, Liwei Lu, Chak Sing Lau, and Vera Sau-Fong Chan
MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice. Int J Mol Sci. 2016; 17(8): 1282
Sheng Yan, Lok Yan Yim, Liwei Lu, Chak Sing Lau, and Vera Sau-Fong Chan
MicroRNA Regulation in Systemic Lupus Erythematosus Pathogenesis. Immune Netw 2014; 14(3): 138–148