Department of Diagnostic Radiology
How useful is an imaging test in identifying early disease, such as Alzheimer's or liver cancer?
What can functional imaging tell us about disease processes at the molecular level?
Major Research Areas
Molecular imaging, including clinical and pre-clinical Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) in Oncology
Advanced MRI and other molecular imaging techniques in neurological diseases:
- Alzheimer's and other neurodegenerative diseases − volumetric MRI, functional MRI, MR perfusion, MR spectroscopy (MRS), Amyloid and Tau PET.
- Neuromyelitis Optica and Multiple Sclerosis − Arterial Spin Labelling (ASL), Diffusion Tensor Imaging (DTI), MRS.
- Brain tumours − surrogate markers in anticancer drug trials using Dynamic Contrast Enhanced (DCE) MR perfusion and MRS.
- Epilepsy − Volumetric MRI, T1 Rho.
- Parkinson's Disease − Susceptibility-weighted Imaging (SWI).
Stroke and cardiovascular imaging:
- Stroke imaging − MR/CT perfusion imaging in evaluation of stroke, MRA/CTA in aneurysm screening and intracranial atherosclerosis, DTI in hemorrhagic stroke, stroke imaging database in HKW cluster.
- Carotid plaque characterisation − Multimodal MRI.
Head and neck imaging:
Multi-modality imaging − 18F-PET-CT and MRI perfusion/diffusion
Molecular and functional imaging in gynaecological and thoracic oncology
- Body diffusion weighted MR imaging (DWI MRI) − application in oncology, quantification of diffusion parameters and technique optimisation on 3T MRI.
- Thoracic radiology − metabolic imaging in idiopathic pulmonary fibrosis and thoracic malignancies based on PET/CT.
- Gynaecological oncology imaging − functional assessment of metabolic activity (PET/CT) in gynaecological malignancies and the use of advanced MRI techniques (e.g. DWI, IVIM, DCE-MRI) in disease diagnosis, treatment response assessment and prognosis.
- Peritoneal imaging − functional assessment using PET/CT, DWI MRI, chemical exchange saturation transfer (CEST) in peritoneal carcinomatosis.
Utilisation of imaging techniques using latest technology in CT, MRI and PET.
- Quantitative radiomics and radiogenomics.
- Using imaging for early detection, cancer characteristics, and response assessment.
- Nasopharyngeal carcinoma
- Hepatocellular carcinoma
- Prostate cancer
- Multiple myeloma
- Low dose CT using iterative reconstruction.
- Cardiovascular imaging using CT and MRI.
- Image processing, big data and machine learning.
Cardiac Magnetic Resonance (CMR):
- Using T1 and T2 mapping for the assessment of myocardial fibrosis and myocardial oedema:
Strain analysis for the assessment of cardiac function and comparing this to echocardiography and other CMR parameters
4D flow in tetralogy of Fallot patients and normal volunteers to investigate wall shear stress, blood flow volume and blood flow velocity
Fast late gadolinium enhancement sequences and its impact on clinical work-flow
- This research is currently focused on three types of patients, (1) Childhood cancer survivors who were given anthracycline chemotherapy, (2) Tetralogy of Fallot patients and (3) chronic kidney disease patients. Correlation with other CMR measurements and other investigations is being investigated.
Cardiac Computed Tomography:
Calcium scoring in rheumatoid arthritis patients with long term follow-up and correlation with other biomarkers and treatment effects on the progression of calcium in the coronary arteries.
Cross-sectional study of pleuroparenchymal fibroelastosis (PPFE) on computed tomography
- Hepatcellular carcinoma − Enhancement pattern on CT/MRI, tracer uptake in PET/CT and underlying genomic changes
- Oesophageal Cancer − Using functional imaging as a surrogate marker for treatment response
- Colorectal Cancer − Using CT/MRI and PET/CT as surrogate markers for treatment response
- Small bowel disease − Using MRI for imaging small bowel disease
- Magnetic resonance fingerprinting
- Fast magnetic resonance techniques
- MR image reconstruction
- Stroke imaging and other neurological diseases and disorders using advanced MRI techniques, with special focus on diffusion imaging.
- Structural brain connectivity
- 2-D/3-D fast MR imaging technique development and reconstruction for fMRI and diffusion weighted/tensor imaging applications (single-shot and multi-shot echo-planar imaging).
- Fat quantification using MRI (acquisition and reconstruction developments).
- Periodically rotated overlapping parallel lines with enhanced reconstruction echo-planar imaging (Propeller-EPI) acquisition and reconstruction developments.
- Artifact reduction of fast MR imaging (Nyquist ghost reduction and geometric distortion correction).
Departmental Postgraduate Admission Advisor
Dr H. Mak
Tel: 2255 3307
Fax: 2855 1652