Department of Pharmacology and Pharmacy
How to make DNA/RNA therapeutics inhalable?
How does the commensal gut bacteria affect our metabolism?
How does our immunity affect the whole body metabolism?
Major Research Areas
Cardiovascular and respiratory research:
- Examination of the signalling pathways involved in the regulation of vascular tone under physiological and pathological situations, including characterisation of hormonal influence and elucidation of potential therapeutic compounds.
- Mechanistic study of the vascular actions of clinically used drugs, such as those for lipid-lowering and antiretroviral, of health supplements, such as vitamin D and milk casein, and of natural products, such as flavonoids and herbal medicine.
- Investigation of the role of ion channels in the function of vascular smooth muscle and endothelial cells.
- Examination of the physiology and pharmacology of nucleoside transporters and drug transporters in cardiovascular system.
- Study of structure-activity relationship of cardiovascular drugs.
- Comprehensive study of prostaglandins and their receptors in the role of vascular and adipose tissue inflammation with the focus on prostaglandin E receptor (EP4) in atherosclerosis, abdominal aortic aneurysm and obesity.
- Study of the telomeric protein, repressor activator protein 1 (Rap 1) in vascular function and lipid metabolism.
- Study of cellular processes underlying the development of chronic airway diseases, including chronic obstructive pulmonary disease, asthma, and obstructive sleep apnea, and the elucidation of potential therapeutic agents.
- Mechanistic study of cellular effects of mesenchymal stem cells in the prevention and management of chronic airway diseases.
Dr S.W.S. Leung
Fax: 2817 0859
Ageing and related diseases − mechanisms and therapeutic targets:
- Sirtuin-1 (SIRT1) as a therapeutic target for ageing-related diseases.
- Drug development and evaluation in obesity-related cardio-metabolic diseases and cancer.
- Applying "omics" approaches for biomarker discovery and developments.
- Integrative study of the role of Toll-like receptors in metabolic diseases and their cardiovascular complications.
- Study of immuno-metabolism with a focus on metabolic function of Toll-like receptor mediated by cell signalling events.
- Gut microbiota in the evolutionary development of Toll-like receptor pathways.
Drug delivery and translational research:
- Particle engineering for improving inhaled drug powder delivery.
- Intranasal and inhalation delivery of nucleic acids (e.g. DNA vaccine, siRNA), proteins and peptides against infectious diseases (e.g. tuberculosis, influenza).
- Cocrystal research for improving drug delivery and manufacturability.
- Development of consistent and stable nanoparticle-based drug delivery systems for superior therapeutic outcomes.
- Novel strategies for enhancing drug solubility and stability.
- Rational design of drug formulations and manufacturing processes by proper statistical software and mathematical modelling.
Pharmacoepidemiology, pharmacoeconomics, pharmacogenetics, pharmacogenomics, and targeted therapies:
- Development of new research methodologies to advance safe medication practice and pharmacoepidemiological research.
- Evaluation of the effectiveness and safety of medications used in the elderly, children, pregnancy and other special patient groups.
- Evaluation of traditional Chinese medicines with respect to toxicology, teratology and concomitant use with conventional Western therapies.
- Pharmacoeconomics of pharmacotherapy in chronic illness and public health interventions − analyses of oral anticoagulants and vaccinations using the willingness-to-pay concept, decision-analytic models and budget impact models.
- Precision medicine of musculoskeletal traits and thyroid disorders.
- Pharmacogenomics of serious drug-related adverse events.
Dr C.L. Cheung
Fax: 2817 0859
Clinical trials and practice based research:
- Design of interventional clinical trials to compare the effectiveness and safety of drugs used in the emergency setting for sedation, epilepsy and pain control.
- Clinical and pharmacy practice-based research to characterise drug-related problems and pharmacists' clinical interventions.
- Assessment of the appropriateness of medications in the older population.
Participation in the journal club and presentation of research seminars at least once a year.
Departmental Postgraduate Admission Advisor
Dr Y. Wang
Fax: 2817 0859