How does bone and joint degeneration develop and can this be controlled to reduce disability?
Can biomaterials modulate tissue and organs regeneration in humans?
Biomechanics of bone and joint; biomechanical analysis of lumbar interbody fusion, new artificial intervertebral disc design and shape memory alloy in spine surgery. Finger fracture fixations, flexor tendon injuries and sports injuries biomechanics; biomechanics of total hip replacement; fixation implant design and development; biomechanical evaluation of biomaterials; cell biomechanics and micro/ nano-biomechanics.
Molecular biology and cellular physiology:
Animal models of musculoskeletal disorders; experimental scoliosis; genetics of degenerative disc disease and osteoarthritis; gene functions in articular and intervertebral joints; proteoglycan metabolism in skeletal tissues. Bone healing and fracture repair; genetic profiles of bone tumours and cell-biomaterial interfacial biology.
Developing disease-modifying agents for treating joint degeneration; programming stem cells or progenitors for joint regeneration; role of fibrosis and its control in tissue repair and mesenchymal stem cell-based therapies.
Orthopaedic biomaterials and musculoskeletal tissue engineering:
Biomaterials for clinical applications; bio-mimetic and 3-D bio-printing; design of new orthopaedic implants; novel bone substitutes and micro- or nano-biomaterials; bioactive bone cement development.
Clinical neurophysiology and neural engineering in orthopaedics:
Neurophysiological detection, neuroimaging, and neurorehabilitation in orthopaedics and spinal disorders; bioelectrical engineering and biomedical devices in orthopaedics.
Clinical, translational, and evidence-based orthopaedics:
Large-scale population-based and epidemiological studies; risk factor assessment; novel imaging; biomarker hunting; "omics" modelling and analyses; data capturing and complex statistics; personalised orthopaedics; clinical patient and surgeon outcome studies.