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Research Ethics

Animal Ethics (CULATR)

Committee on the Use of Live Animals in Teaching and Research (CULATR)

  1. Center for Alternatives to Animal Testing (Altweb)
  2. Fund for the Replacement of Animals in Medical Experiments (FRAME)
  3. Norwegian Reference Centre for Laboratory Animal Science and Alternatives (NORINA)
  4. National Centre for the Replacement, Refinement and Reduction of Animals in Research
  5. 3Rs – Reduction (experimental design)

Section 7

  1. The Design of Animal Experiments: Reducing the Use of Animals in Research through Better Experimental Design (RSM, 2002)
    (available at the Yu Chun Keung Medical Library; call number: M616.0273 D4)
  2. Principles of Experimental Design for the Life Sciences (CRC Press, 1996)
    (available at Hing Wai Storage; call number: D610.72 S46)
  3. Statistics and Experimental Design for Toxicologists (Third Edition) (CRC Press, 1999)
    (available at Main Library; call number: 615. 900727 G123 s)
  4. Statistics for Experimenters: Design, Innovation, and Discovery (Second Edition) (John Wiley & Sons. Inc.)
    (available at Yu Chun Keung Medical Library: call number: M001.424 B78 s)
  5. Experimental Design for Biologists (Cold Spring Harbour Laboratory Press, 2007)
    (available at Yu Chun Keung Medical Library: call number: M570.724 G54)

Section 11

  1. Saphenous vein puncture for blood sampling of the mice (2005)
  2. The UKCCCR guidelines for the welfare of animals in experimental neoplasia (1997)
  3. Home Office Guidance Note: Water and food restriction for scientific purposes (2003)
  4. Home Office Guidance Note: Antibody production – Principles for protocols of minimal severity (2000)
  5. CCAC Guidelines on Antibody Production, Canadian Council on Animal Care (2002)
  6. Refinement and reduction in production of genetically modified mice (2003)
  7. Laboratory birds: refinements in husbandry and procedures (2001)
  8. Refining procedures for the administration of substances
  9. ILAR Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research (2003)
  10. Guide for the Care and Use of Laboratory Animals, NRC, USA (2011)
  11. NIH Guidelines for Research Involving Recombinant DNA Molecules
  12. AFCD Code of Practice for Care and Use of Animals for Experimental Purposes (2004)
  13. Veterinary Care for Laboratory Animals, Laboratory Animal Unit, HKU (2005)
  14. NIH Guidelines for Survival Rodent Surgery, USA (2017)
  15. Harmonisation of Animal Care and Use Guildlines, Science (2006)
  16. NIH Guidelines for Ascitis Production in Mice (2016)
  17. Sub-mandibular bleeding of mice (2005)

Section 11(c)

  1. Pain and distress in laboratory rodents and lagomorphs, Laboratory Animals 28, 97-112 (1994)
  2. Handbook of laboratory animal management and welfare, S. Wolfensohn et al (2003)
    (available at the Main Library; call number: 636.0885 W855 h)
  3. Formulary for laboratory animals, C.T. Hawk et al (2005)
    (available at the Yu Chun Keung Medical Library; call number: M 636.089514 F72)
  4. Laboratory animal anaesthesia, P. Flecknell (1996)
    (available at HKU Library; call number: 636.0885 F5)
  5. Anaesthesia and analgesia in laboratory animals, D.F. Kohn et al (2008)
    (available online via HKU Library:
  6. Guidelines for animal surgery in research and teaching, Am J Vet Res, 54, 1544-1559 (1993)
    available at
  7. Pain management in animals. P. Flecknell & A. Waterman-Pearson (2000)
    (available at the Yu Chun Keung Medical Library; call number: M 636.08960472 P1)
  8. The assessment and alleviation of pain and distress in research animals (2007)

Section 11(e)

  1. CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing (1998)

  2. ILAR Report: Humane endpoints for animals used in biomedical research and testing (2000)

  3. NIH Guidelines for Endpoints in Animal Study Proposals, USA (2016)

  4. Guidelines for the Assessment and Management of Pain in Rodents and Rabbits, ACLAM (2006)

Section 11(j)

  1. AVMA Guidelines for the Euthanasia of Animals (2013 Edition)
  2. NIH Guidelines for the Euthanasia of Rodent Fetuses and Neonates (2016)
  3. NIH Guidelines for Euthanasia of Rodents Using Carbon Dioxide (2017)

Section 11(k)

  1. Occupational health and safety in the care and use of research animals, NRC (1997)
  2. Biosafety in microbiological and biomedical laboratories, CDC (2009)

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