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Research Highlights

Achievements

  • Developed an oral arsenic preparation to treat leukaemia, a first patented prescription drug developed entirely in Hong Kong
  • Identified and characterised cancer stem cells responsible for metastasis in colorectal cancer, and the development of liver cancer
  • Discovered  a new mechanism causing Lynch Syndrome that has become a diagnostic test adopted worldwide
  • Hepatitis B virus infection and hepatocellular carcinoma: from diagnosis and treatment of chronic carrier status, mechanisms of hepatocellular carcinogenesis, to development of novel treatment modalities including live-donor liver transplantation
  • Comprehensive genomic study of gastric and liver cancers
  • Critical insights into the disease mechanisms of premature ageing, deafness, and digit development, through functional genomics and genetics
  • Generation of a mouse model for Brachydactyly type A1 by the TCF providing new insights into the development and formation of joints
  • Genetic and sequence analyses in the identification of a novel risk factor linked to degeneration of the spine and back pain
  • Extensive cohort studies using a theoretical perspective and cutting edge methods to explicate etiology and evaluate contextually specific prevention strategies
  • Defined the risk and predictors of relapse in patients with early psychosis in remission; ensuring favorable clinical outcome 
  • Discovered the SARS coronavirus in 2003; pivotal in the fight against SARS
  • Influenza and other emerging viruses : from pathogen evolution, mode of transmission, clinical presentation, to drug development and prevention through national and global policy formulation and evaluation 
  • Leading research on adipokines and adipose-derived hormones
  • Research on metabolic diseases: identification of novel biomarkers for risk prediction and drug development in prevention and management of diabetes mellitus, obesity, cardiovascular diseases and thyrotoxic periodic paralysis 
  • Adjudicated by the RAE panel to have the highest relative percentage as well as the highest absolute number of world leading (4*) and internationally excellent (3*) research outputs, external peer-reviewed grants and esteem measures under the Health Sciences Panel. 
  • Fielded the most number of candidates (296 staff). 
  • 53 researchers listed as Top 1% Scientists in the World
  • 256 Highly Cited Papers