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Research Highlights

 

 

Cancer

Highlights

  • Developed an oral arsenic preparation to treat leukaemia, a first patented prescription drug developed entirely in Hong Kong
  • Identified and characterised cancer stem cells responsible for metastasis in colorectal cancer, and the development of liver cancer
  • Discovered a new mechanism causing Lynch Syndrome that has become a diagnostic test adopted worldwide
  • Hepatitis B virus infection and hepatocellular carcinoma: from diagnosis and treatment of chronic carrier status, mechanisms of hepatocellular carcinogenesis, to development of novel treatment modalities including live-donor liver transplantation
  • Comprehensive genomic study of gastric and liver cancers

UGC Area of Excellence

UGC Theme-based Research Scheme

Partner State Key Laboratory

Strategic Project

Cardiometabolic Diseases & Healthy Aging

Highlights

  • Leading research on adipokines and adipose-derived hormones
  • Research on metabolic diseases: identification of novel biomarkers for risk prediction and drug development in prevention and management of diabetes mellitus, obesity, cardiovascular diseases and thyrotoxic periodic paralysis 

UGC Theme-based Research Scheme

Partner State Key Laboratory

Emerging Infectious Disease

Highlights

  • Discovered the SARS coronavirus in 2003; pivotal in the fight against SARS
  • Human and animal (poultry, swine, wild birds) influenza viruses and other emerging viruses: from ecology, pathogen evolution, clinical presentation, innate immune responses, to drug development and prevention through national and global policy formulation and evaluation
  • Provided understanding on the evolutionary history, emergence and pathogenesis of the 2009 pandemic H1N1 virus; avian influenza viruses H5N1, H9N2 and H7N9; and MERS
  • Provided evidence-based options for the control of these viruses in poultry and in humans
  • Infectious disease epidemiology: insights into influenza transmission in the community; effectiveness and impact of control measures; modes of transmission of viruses; vaccination effectiveness; immunity to infections; mathematical models to assess the potential benefits and resource requirement of mitigation and surveillance strategies

UGC Area of Excellence

UGC Theme-based Research Scheme

State Key Laboratory

Collaborative Laboratories

Stem Cell, Development and Regenerative Biology

Highlights

  • Areas of focus include: basic and clinical stem cell biology, orthopaedic engineering, blood and cancer stem cells, stem cell immunology and bio-artificial tissue engineering
  • Working towards establishment of stem cells with totipotency features from mammalian species and characterisation of them using molecular and functional approaches including single cell genomics
  • Critical insights into the disease mechanisms of premature ageing, deafness, and digit development, through functional genomics and genetics
  • Generation of a mouse model for Brachydactyly type A1 by the TCF providing new insights into the development and formation of joints
  • Genetic and sequence analyses in the identification of a novel risk factor linked to degeneration of the spine and back pain

UGC Area of Excellence

UGC Theme-based Research Scheme

Collaborative Centre