| James C.B. LI, Ph.D |
| Research Assistant Professor, Molecular Chinese Medicine Laboratory/Cytokine Biology Group LKS Faculty of Medicine, The University of Hong Kong |
Academic qualifications
| Institution | Degrees conferred | Major subject |
| The University of Hong Kong | B.Sc | Biology |
| Chinese University of Hong Kong | M.Phil | Cancer |
| The University of Hong Kong | Ph.D | Viral Immunology |
Awards
| Dates | Organization |
| 2004 | Student Research Presentation Award American Society for Virology Annual Meeting, Montreal |
| 2008 | Best Abstract and Presentation Award, The Annual Scientific Meeting and General Meeting 2008, Hong Kong Society for Immunology |
| 2008 | 2nd Prize, Oral Presentation Award, The First Scientific Meeting And The Second Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases |
| 2009 | 2nd Prize, Oral Presentation Award, The Second Scientific Meeting And The Third Annual General Meeting Of The Hong Kong Society For Paediatric Immunology And Infectious Diseases |
Research Interests:
- Pathogenesis of HIV and other microbes, Cytokine biology and molecular signaling, Molecular Chinese Medicine
Grants Funded as Principal Investigator
- HKU CRACG Grant, 2007
- Research Fund for the Control of Infectious Diseases, HKSAR Government, #09080542
Representative publications:
- Li JC, Lee DC, Cheung BK, Lau AS. Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response. FEBS Lett. 2005 Jun 6;579(14):3055-62 *
- Cheung BK, Lee DC, Li JC, Lau AS. A Role for Double-stranded RNA-activated Protein Kinase PKR in Mycobacterium-induced Cytokine Expression. J Immunol. 2005 Dec 1;175(11):7218-25
- Li JC, Lau AS. A role for mitogen-activated protein kinase and Ets-1 in the induction of interleukin-10 transcription by human immunodeficiency virus-1 Tat. Immunology. 2007 Jul;121(3):337-48 *
- Cheng SM, Xing B, Li JC, Cheung BK, Lau AS. Interferon-gamma regulation of TNFalpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells. Int J Cancer. 2007 Sep 15;121(6):1190-6
- Li JC#, Cheng SM#, Lin BS, Lee DC, Liu L, Chen Z, Lau AS. HIV-1 trans-activator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling. Blood. 2009 May 21;113(21):5192-201. *
- Lee DC, Yang CL, Chik SC, Li JC, Rong JH, Chan GC, Lau AS. Immunomodulatory effect of Panax ginseng on human promonocytic U937 cells. J Transl Med. 2009 May 14;7:34
- Yim HC, Li JC, Lau JS, Lau AS. HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: microbial interactions in HIV infection. AIDS. 2009 Jul 31;23(12):1473-84
- Yang CL, Chik SC, Li JC, Cheung BK, Lau AS. Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. J Med Chem. 2009 Nov 12;52(21):6707-15
- Li JC, Yim HC, Lau AS. The role of HIV-1 Tat regulatory protein in AIDS pathogenesis: its effects on cytokine dysregulation and contribution to opportunistic infection. Editorial Review. AIDS,2010 Jul 17;24(11):1609-23 *
- Li JC, Au KY, Fang JW, Yim CH, Lau AS. HIV-1 trans-activator protein dysregulates IFN-gamma signaling contributes to the abrogation of autophagy induction. AIDS Nov 19, 2010 (Epub ahead of print). *
* Denotes LI J.C. is the first author/co-first author; # JCBL and SMC contributed equally to this project
Patent:
- US Patent: Novel compound and uses thereof for treating inflammation and modulating immune responses., Type: Provisional. PI: Allan SY Lau. Co-I: Cindy LH Yang, James CB Li, and Stanley C Chik. Media: US Provisional patent Application Serial # 61/143-925. Assignees: HKU Versitech Limited and Purapharm International. Priority date for IP: 2009.
Contact Information:
Dr. James C.B. LI
Email: jamesli@hku.hk
Phone: (852) 2819-9356
