Research Projects
The Use of Particle Engineering Technologies to Develop Pulmonary and Nasal Drug Delivery Platform of Therapeutic Biomacromolecules


Programme(s) to which this project applies:
☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

The goal of this project is to address the drug delivery issue by developing novel inhaled and nasal dry powder formulations for the treatment of lung diseases such as respiratory infections, severe asthma and lung cancer.  Biomarcomolecules including RNAs and antibodies are increasingly important classes of therapeutics yet their administration is largely limited to the invasive injection routes. With our extensive experience in developing pulmonary delivery system, we anticipate that two particle engineering techniques, namely spray drying (SD) and spray freeze drying (SFD) can be used to produce inhalable and nasal formulation of therapeutic biomacromolecules. The key to success involves a rational design of formulation in combination with the optimal process parameters in order to provide maximal protection to the active drugs and achieve good drug absorption while exhibit excellent aerosol properties for efficient nasal and lung deposition with satisfactory pharmacokinetic profile.

Dr JKW Lam, Department of Pharmacology and Pharmacy

Biography
Laboratory Homepage
jkwlam@hku.hk

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information. 

Research @ Department of Pharmacology and Pharmacy