Programme(s) to which this project applies:

☒ MPhil/PhD ☑ MRes ☒ URIS

Objective and Significance:

To study the signaling pathway mediated by Small Rho GTPases in cancer metastasis

Research Plan and Methodology:

  1. To evaluate the expression of the downstream effectors of small Rho GTPases (e.g. p21-activated protein kinases) in clinical tumour samples using techniques like qPCR, RT-PCR, Western blotting, immunohistochemical staining.
  2. To evaulate the tumorigenecity of target gene using functional assay like, focus formation, soft agar growth and nude mice injection assay.
  3. To study the signaling pathway by which target genes exert their effects, particularly in cell motility and invasion. The approach used will mainly be transwell migration and confocal microscopy.

Dr YP Ching, School of Biomedical Sciences


For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information.