Research Projects
Mechanistic understanding of epigenetic inheritance during DNA replication


Programme(s) to which this project applies:
☑ MPhil/PhD ☒ MRes[Med] ☒ URIS

Epigenetic mechanisms regulate multiple aspects of normal development. Defects in epigenetic regulation have been implicated in numerous developmental disorders, premature aging and even cancers. Epigenome to a certain degree defines the specificity of each cell type, and epigenetic mechanisms constitute “memories” of cell identity, for example, to help stem cell maintain the pluripotency, to make sure somatic cells differentiate into the same cell type. In this project, we will apply an integrative structural biology approach by combining cryo-electron microscopy (cryo-EM) and X-ray crystallography with biochemical, molecular and cell biology methods to unravel the molecular mechanisms of epigenetic inheritance during replication.

Professor C Qian, School of Biomedical Sciences

HKU Scholars Hub
ORCID
cmqian@hku.hk

 

For more information or to express interest for this project, please email the supervisor or the specified contact point in the project description.  Interested candidates are advised to enclose with your email:

  1. your CV,
  2. a brief description of your research interest and experience, and
  3. two reference letters (not required for HKUMed UG students seeking MRes[Med]/URIS projects).

Information on the research programme, funding support and admission documentations could be referenced online at the Research Postgraduate Admissions website. General admission enquiries should be directed to rpgmed@hku.hk.

HKUMed MBBS students interested in the Master of Research in Medicine (MRes[Med]) programme may visit the programme website for more information.  

HKUMed UG students interested in the Undergraduate Research Internship Scheme (URIS) may visit the scheme’s website for more information. 

Research @ School of Biomedical Sciences