Research

High Impact Publications


Dec 2019

Intensification with dipeptidyl peptidase-4 inhibitor, insulin, or thiazolidinediones and risks of all-cause mortality, cardiovascular diseases, and severe hypoglycemia in patients on metformin-sulfonylurea dual therapy: A retrospective cohort study
PLoS Medicine, 1 December 2019, Vol.16(12), p.e1002999

Dec 2019

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses
Gastroenterology, December 2019, Vol.157(6), pp.1556-1571.e5

Nov 2019

Upconversion-like Photolysis of BODIPY-Based Prodrugs via a One-Photon Process
Journal of the American Chemical Society, November 6, 2019, Vol.141(44), pp.17482-17486

Nov 2019

Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients
Gut, 26 November 2019, Vol.68(11), p.1979

Oct 2019

Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
Nature Communications, 15 October 2019, Vol.10(1), pp.4681

Aug 2019

Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9
Nature Methods, August 2019, Vol.16(8), pp.722-730

Jun 2019

Aberrant Super-Enhancer Landscape in Human Hepatocellular Carcinoma
Hepatology, June 2019, Vol.69(6), pp.2502-2517

May 2019

Injectable cell-encapsulating composite alginate-collagen platform with inducible termination switch for safer ocular drug delivery
Biomaterials, May 2019, Vol.201, pp.53-67

Apr 2019

Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection
Gastroenterology, April 2019, Vol.156(5), pp.1392-1403.e7

Mar 2019

Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank
BMJ, 06 March 2019, Vol.364

Feb 2019

Trazodone use and risk of dementia: A population-based cohort study
PLoS Medicine, 01 February 2019, Vol.16(2), p.e1002728

Feb 2019

Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader
Nature Communications, February 20, 2019, Vol.10(1), p.852

Feb 2019

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
Nature Communications, February 12, 2019, Vol.10(1), p.716

Feb 2019

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
The Journal of Clinical Investigation, February 1, 2019, Vol.129(2), pp.834-849

Jan 2019

Temperature-responsive tungsten doped vanadium dioxide thin film starves bacteria to death
Materials Today, January 2019, Vol.22, pp.35-49

Jan 2019

Indirect protection from vaccinating children against influenza in households
Nature Communications, January 10, 2019, Vol.10(1), p.106

Dec 2018

Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study
The Lancet Respiratory Medicine, December 01, 2018, Volume 6, ISSUE 12, P925-934.

Dec 2018

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening
Cell Stem Cell, 06 December 2018, Vol.23(6), pp.882-897.e11

Nov 2018

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures
The Lancet Respiratory Medicine, November 2018, Vol.6(11), pp.846-854

Nov 2018

Chronic hepatitis B virus infection
The Lancet, November 24, 2018, Volume 392, ISSUE 10161, P2313-2324

Oct 2018

Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases
The Lancet Psychiatry, October 2018, Vol.5(10), pp.824-835

Jul 2018

Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals
Gastroenterology, July 2018, Vol.155(1), pp.67-75

May 2018

Long-term effects of discontinuation from antipsychotic maintenance following first episode schizophrenia and related disorders: a 10 year follow-up of a randomised, double-blind trial
The Lancet Psychiatry, May 2018, Vol.5(5), pp.432-442

May 2018

Association of an Early Intervention Service for Psychosis With Suicide Rate Among Patients With First-Episode Schizophrenia-Spectrum Disorders
JAMA Psychiatry, 01 May 2018, Vol.75(5), pp.458-464

Mar 2018

Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial
Eur Heart J. 2018 Mar 21;39(12):1028-1037

Jan 2018

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study Free
Gut, 2018 Jan;67(1):28-35
 

Jan 2018

Characterizing the dynamics underlying global spread of epidemics
Nature Communications, January 2018, Volume 9, Article number: 218

Jan 2018

Five-Year Effectiveness of the Multidisciplinary Risk Assessment and Management Programme–Diabetes Mellitus (RAMP-DM) on Diabetes-Related Complications and Health Service Uses—A Population-Based and Propensity-Matched Cohort Study
Diabetes Care, January 2018, Vol.41(1), pp.49-59

 

Dec 2017

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
Gut, 2017 Dec;66(12):2149-2159

Dec 2017

Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development
Cell Research, 2017 Dec;27(12):1466-1484

Oct 2017

Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
Nat Commun. 2017 Oct 30;8(1):1185

Oct 2017

Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease
Nature Genetics, Volume 49, No. 12, Pages 1722-1730, October 2017

Sep 2017

Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies
Journal of Clinical Oncology, Volume 35, No. 25, Pages 2885-2892, September 2017

Sep 2017

The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity
Cell Metab. 2017 Sep 5;26(3):493-508

Aug 2017

TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
Gut, 2017 Aug;66(8):1496-1506

Aug 2017

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
Nature Neuroscience, Volume 20, No. 10, Pages 1342-1349, August 2017

Mar 2017

Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study
The Lancet Infectious Diseases, Volume 17, ISSUE 3, P339-347, March 01, 2017

 

Dec 2016

Fractional dosing of yellow fever vaccine to extend supply: a modelling study
The Lancet, Volume 388, No. 10062, Pages 2904–2911, December 2016

Oct 2016

Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia
Science Translational Medicine, Vol. 8, Issue 359, pp. 359ra129, October 5, 2016

Aug 2016

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
Nature Genetics, Volume 48, No 8, Pages 940–946, August 2016

Jun 2016

Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice
Circulation, Volume 133, Issue 24, Pages 2434-2446, June 2016

Jun 2016

Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin
JAMA Intern Med, Volume 176, Issue 6, Pages 828-834, June 2016

Jun 2016

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
Gut, 66(9):1645-1656, September 2017, Epub 2016 Jun 21

Mar 2016

Routine Pediatric Enterovirus 71 Vaccination in China: a Cost-Effectiveness Analysis
PLOS Medicine, Volume 13, No 3, March 2016

Feb 2016

Quantifying influenza virus diversity and transmission in humans
Nature Genetics (Letter), Volume 48, No 2, Pages 195-200, February 2016

Feb 2016

Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial
The Lancet Infectious Diseases, Volume 16, No. 2, p209–218, February 2016.

Jan 2016

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
Science, Vol. 351, Issue 6268, pp. 81-84, 01 Jan 2016 (On-line print17 Dec 2015).

 

Oct 2015

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Molecular Cell (October 2015), Volume 60, Issue 1, p163-176

Sep 2015

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study
Gastroenterology, Volume 149, Issue 3, Pages 586–595, September 2015.

Sep 2015

Clinical Benefit of Warfarin in Dialysis Patients With Atrial Fibrillation
Journal of the American College of Cardiology, Volume 66, Issue 11, Pages 1310-1311, 15 September 2015.

Aug 2015

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice
Gastroenterology, Vol. 149, Issue 7, p1837–1848, Published online: August 7 2015.

Aug 2015

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation
Cell Metabolism, Volume 22, Issue 2, p279–290, 4 August 2015.

Aug 2015

Impact of Secondhand Smoke Exposure on Smoking Cessation in Cardiac Patients
Journal of the American College of Cardiology, Volume 66, Issue 5, 592-3, August 2015

Jun 2015

Dissemination, divergence and establishment of H7N9 influenza viruses in China
Nature, Volume 522, Issue 7554, 102–105, 04 June 2015.

May 2015

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
Circulation, 2015 May 26;131(21):1861-71.

Apr 2015

One More “C” for CHA2DS2-VASc Score?
Journal of the American College of Cardiology, Volume 65, Issue 15, Pages 1602-1603, 21 April 2015.

 

Oct 2013

The genesis and source of the H7N9 influenza viruses causing human infections in China
Nature, 502 (7470) : 241–244, October 2013

Sept 2013

Prognostic Value of Preoperative Right Ventricular Geometry and Tricuspid Valve Tethering Area in Patients Undergoing Tricuspid Annuloplasty
Circulation, September 2013 (online published).

Aug 2013

Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study.
Circulation, 128 (7) : 687-93, August 2013.

Aug 2013

Reducing Treatment Decision Conflict Difficulties in Breast Cancer Surgery: A Randomized Controlled Trial
Journal of Clinical Oncology, 31 (23) : 2879-2885, August 2013.

Jul 2013

Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases
The Lancet, 382 (9887), 129 - 137, July 2013.

Jul 2013

Human infection with avian influenza A H7N9 virus: an assessment of clinical severity
The Lancet, 382 (9887) : 138–145, July 2013.

Jul 2013

Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs.
Science. Vol. 341, Issue 6142, pp. 183-186, 12 Jul 2013.

Jun 2013

Association between adverse clinical outcome in human disease caused by novel infl uenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance
The Lancet, 381 (9885) : 2273–2279, June 2013.

Jun 2013

Detection of mild to moderate influenza A/H7N9 infection by China’s national sentinel surveillance system for influenza-like illness: case series
British Medical Journal, 346 : 3693, June 2013.

Apr 2013

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Nature, 496 (7443) : 110–113, April 2013.

Feb 2013

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
Nature Medicine, 19 (2) : 209 - 216, February 2013

 

Sep 2012

Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes Mellitus-Induced Impairment in Vascular Function and Reendothelialization via Induction of Heme Oxygenase-1 in Mice
Circulation. 126 (10) : 1267-1277, September 2012.

Sep 2012

Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3
Nature Genetics, 44 (9) : 1026–1029, September 2012.

Aug 2012

Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis
Circulation, 126 (6) : 729-40, August 2012.

Jul 2012

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
Nature Genetics, 44 (7) : 765–769, July 2012.

May 2012

Magnetically controlled growing rods for severe spinal curvature in young children: a prospective case series
The Lancet, 379 (9830) : 1967-1974, May 2012.

May 2012

Precursor microRNA-programmed silencing complex assembly pathways in mammals
Molecular Cell, 46 (4) : 507-517, May 2012.

Nov 2011

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Science, 334 (6057) : 806-809, November 2011

Oct 2011

Estimating Infection Attack Rates and Severity in Real Time during an Influenza Pandemic: Analysis of Serial Cross-Sectional Serologic Surveillance Data
PLoS Medicine, 8 (10): e1001103, October 2011.

Oct 2011

Sequential Establishment of Stripe Patterns in an Expanding Cell Population
Science, 334 (6053) : 238-241, October 2011

Oct 2011

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
Nature Genet, 43 (12) : 1219-23, Oct 2011

Sep 2011

Human Sperm Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida
Science, 333 (6050) : 1761-1764, September 2011.

Sep 2011

Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.
J Clin Invest, Volume 121, Issue 9 : 3467-78, September 1, 2011.

Jun 2011

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation
Cell Stem Cell, 9 (1) : 50–63, July 2011.

Jun 2011

Epidemiological Characteristics of 2009 (H1N1) Pandemic Influenza Based on Paired Sera from a Longitudinal Community Cohort Study
PLoS Medicine, 8 (6): e1000442, June 2011.

Jun 2011

Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score
The Lancet Oncology, 12 (6): 568-574, June 2011.

May 2011

Long-term evolution and transmission dynamics of swine influenza A virus
Nature, 473 (7348) : 519–522, May 2011

Dec 2010

miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1
Cell Stem Cell, 7 : 6, 694-707, December 2010

Dec 2010

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects
Cell Stem Cell, 8 (1): 31-45, December 2010.

Oct 2010

SOX9 induces and maintains neural stem cells
Nature Neuroscience, 13 (10) : 1181–1189, October 2010

Aug 2010

Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial
British Medical Journal, 341 : 4024, August 2010

Aug 2010

Effect of an Advocacy Intervention on Mental Health in Chinese Women Survivors of Intimate Partner Violence: A Randomized Controlled Trial
Journal of the American Medical Association, 304 : 5, 536-543, August 2010

Jun 2010

Identification of influenza A nucleoprotein as an antiviral target
Nature Biotechnology, 28 : 6, 600–605, June 2010

Jun 2010

Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
Science, 328, 1529, June 2010

Jun 2010

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
Cell Stem Cell, 6 : 6, 603-615, June 2010

Jun 2010

Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households
The New England Journal Medicine, 362 : 2175-2184, June 2010

Mar 2010

Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice
Circulation, 121 (9):1113-1123, March 2010

Mar 2010

Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1
Molecular Cell 37 (6) : 854–864, March 2010

 

Nov 2006

Effect of obesity in patients with coronary artery disease
The Lancet, 368 : 9548, 1645-1645, November 2006

Oct 2006

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
Nature Genetics, 38 : 10, 1178-1183, October 2006

Sep 2006

Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model
Circulation, Volume 114, Issue 10, p.1000-11, September 5, 2006.

Sep 2006

Reducing the impact of the next influenza pandemic using household-based public health interventions
PLoS Medicine, Volume 3, Issue 9, p.1532-1540, September 2006.

Jul 2006

The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication
Nature Cell Biology, 8, 717 – 724, July 2006

Apr 2006

Influenza-Associated Hospitalization in a Subtropical City
PLoS Medicine, Volume 3, Issue 4, p.485-492, April 2006.

Mar 2006

Cytotoxic therapy for severe avian influenza A (H5N1) infection
The Lancet, 367 : 9513, 870-873, March 2006

Mar 2006

Entecavir versus Lamivudine for Patients with HBeAg-Negative Chronic Hepatitis B
The New England Journal of Medicine, 354 : 10, 1011-1020, March 2006

Feb 2006

Clozapine Alone versus Clozapine and Risperidone with Refractory Schizophrenia
The New England Journal of Medicine,. 354 : 5, p. 472-482, February 2006.

Feb 2006

White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function
Journal of Clinical Oncology, v.24, (6), p,884-890, February 2006.

Jan 2006

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
Nature Genetics, 38 : 1, 38-46, January 2006

 

Oct 2003

Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China
Science, 302 : 5643, 276-278, October 2003

Jul 2003

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
Journal of Clinical Investigation, 112 : 1, 91-100, July 2003

Jun 2003

Transmission Dynamics of the Etiological Agent of SARS in Hong Kong: Impact of Public Health Interventions
Science, 300 : 5627, 1961-1966, June 2003

May 2003

Development of a standard treatment protocol for severe acute respiratory syndrome
The Lancet, 361 : 9369, 1615-1617, May 2003

May 2003

Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study
The Lancet, 361 : 9371, 1767-1772, May 2003

May 2003

Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS)
The Lancet, 361 : 9368, 1519-1520, May 2003

May 2003

Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong
The Lancet, 361 : 9371, 1761-1766, May 2003

May 2003

Lung pathology of fatal severe acute respiratory syndrome
The Lancet, 361 : 9371, 1773-1778, May 2003

May 2003

A Cluster of Cases of Severe Acute Respiratory Syndrome in Hong Kong
The New England Journal of Medicine, 348 : 20, 1977-1985, May 2003

Apr 2003

Coronavirus as a possible cause of severe acute respiratory syndrome
The Lancet, 361 : 9366, 1319-1325, April 2003

Jan 2003

Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
The Lancet, 361 : 9351, 47-49, January 2003