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HKUMed researchers reveal the clinical characteristics and epidemiological trend of COVID-19 infected children

09 June 2020

Researchers at the Department of Surgery and the Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine of The University of Hong Kong (HKUMed) collaborated with researchers in Wuhan to conduct a study on the symptoms of 244 children diagnosed with SARS-CoV-2 mainly around the lockdown period in Wuhan from January to March 2020. The study specifically compared SARS-CoV-2 infected children presenting with gastrointestinal (GI) symptoms with those without GI symptoms. The findings are now published in medical journal Gut [link to the publication].

The study shows that GI symptoms were present in 13.9% of all SARS-CoV-2 infected children (compared to 11.6% in adults in a previous study), and that smaller children (two years old or younger) were more likely to have GI symptoms than older children. One particular result of interest was the high detection rate of the SARS-CoV-2 virus (about 35%) in the stool samples of 105 children-patients tested by RT-PCR; and the detection rate was also similarly high even in those without any GI symptoms and those who were completely asymptomatic.

“Taking other recent reports on finding live SARS-CoV-2 detected on electron microscopy in stool samples and elevated concentrations of SARS-CoV-2 detected in patients’ toilet areas into account, our study further strengthens that faecal-oral transmission remains a possibility. There is an absolute need for contact precaution when dealing with the excreta of COVID-19 children, whether they have GI symptoms or not. The public should remain on guard at all times,” said Dr Kenneth Wong Kak-yuen, Clinical Associate Professor, Chief of Division of Paediatric Surgery, Department of Surgery, HKUMed, who led the research.

 

About the research team

The research was led by Dr Kenneth Wong Kak-yuen, Clinical Associate Professor, Chief of Division of Paediatric Surgery, Department of Surgery, HKUMed. Other members of the research team include: Dr Patrick Chung Ho-yu, Clinical Assistant Professor; Professor Paul Tam Kwong-hang, Li Shu-Pui Professor in Surgery, Director of Dr Li Dak-Sum Research Centre and Chair Professor of Paediatric Surgery, Department of Surgery, HKUMed; Dr Gilbert T Chua, Honorary Tutor; Dr Patrick Ip, Clinical Associate Professor; Professor Godfrey Chan Chi-fung, Tsao Yen-Chow Professorship in Paediatrics and Adolescent Medicine, Clinical Professor and Head of  Department of Paediatrics and Adolescent Medicine, HKUMed; Professor Ian Wong Chi-kei, Lo Shiu Kwan Kan Po Ling Professorship in Pharmacy, Professor and Head of Department of Pharmacology and Pharmacy, HKUMed; and collaborators from Wuhan Children’s Hospital and Union Hospital, Wuhan, mainland China.

 

For the latest update from HKUMed on COVID-19:

https://www.med.hku.hk/en/covid-19

 

Media enquiries

Please contact LKS Faculty of Medicine of The University of Hong Kong by email
(medmedia@hku.hk).

Members of HKUMed research team (from left) Professor Ian Wong Chi-kei, Lo Shiu Kwan Kan Po Ling Professorship in Pharmacy, Professor and Head of Department of Pharmacology and Pharmacy; Dr Gilbert T Chua, Honorary Tutor, Department of Paediatrics and Adolescent Medicine; Dr Kenneth Wong Kak-yuen, Clinical Associate Professor, Chief of Division of Paediatric Surgery, Department of Surgery; Professor Paul Tam Kwong-hang, Li Shu-Pui Professor in Surgery, Director of Dr Li Dak-Sum Research Centre and Chair Professor of Paediatric Surgery, Department of Surgery; Dr Patrick Ip, Clinical Associate Professor, Department of Paediatrics and Adolescent Medicine; Professor Godfrey Chan Chi-fung, Tsao Yen-Chow Professorship in Paediatrics and Adolescent Medicine, Clinical Professor and Head of Department of Paediatrics and Adolescent Medicine and Dr Patrick Chung Ho-yu, Clinical Assistant Professor, Department of Surgery.