HKUMed on COVID-19

Our Research

08 October 2020

BMJ Open: Anxiety levels, precautionary behaviours and public perceptions during the early phase of the COVID-19 outbreak in China: a population-based cross-sectional survey

06 October 2020

British Journal of Clinical Pharmacology: Using genetics to understand the role of antihypertensive drugs modulating angiotensin‐converting enzyme in immune function and inflammation

29 September 2020

MedEdPublish: COVID-19 – A Covert Catalyst for Pedagogical Stocktake and Transformation: Perspectives of a Global Hub

24 September 2020

The Lancet: Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe

23 September 2020

Clinical Infectious Diseases: Serum antibody profile of a patient with COVID-19 reinfection

21 September 2020

The Lancet: What can we expect from first-generation COVID-19 vaccines?

Current Opinion in HIV and AIDS: The Coronavirus Disease 2019 pandemic - how does it spread and how do we stop it?

18 September 2020

Emerging Infectious Diseases: In-Flight Transmission of Severe Acute Respiratory Syndrome Coronavirus 2

17 September 2020

Nature Medicine: Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong
Link to press release

Infection: Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms

Emerging Microbes & Infections: Short- and Potential Long-term Adverse Health Outcomes of COVID-19: A Rapid Review

Eurosurveillance: Letter to the Editor: COVID-19 cases among school-aged children and school-based measures in Hong Kong, July 2020

15 September 2020

International Journal of Infectious Diseases: Development and Validation of Risk Prediction Models for COVID-19 Positivity in a Hospital Setting

International Journal of Infectious Diseases: Mental health crisis under COVID-19 pandemic in Hong Kong, China

14 September 2020

International Journal of Environmental Research and Public Health: Social Distancing Compliance under COVID-19 Pandemic and Mental Health Impacts: A Population-Based Study

11 September 2020

Emerging Infectious Diseases: Early Insights from Statistical and Mathematical Modeling of Key Epidemiologic Parameters of COVID-19

Epidemiology & Infection: Ecologic association between influenza and COVID-19 mortality rates in European countries

28 August 2020

JACC Cardiovascular Imaging: Recovered COVID-19 Patients Show Ongoing Subclinical Myocarditis as Revealed by Cardiac Magnetic Resonance Imaging

25 August 2020

Clinical Infectious Diseases: COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing

Nature Communications: A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Influenza and Other Respiratory Viruses: Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2

17 August 2020

Nature Immunology: ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection
Link to press release

Infection Control & Hospital Epidemiology: Absence of nosocomial influenza and respiratory syncytial virus infection in the coronavirus disease 2019 (COVID-19) era: implication of universal masking in hospitals

Nature Medicine: Reply to: Is presymptomatic spread a major contributor to COVID-19 transmission?

14 August 2020

Science Advances: Viruses harness YxxØ motif to interact with host AP2M1 for replication: a vulnerable broad-spectrum antiviral target

12 August 2020

EClinicalMedicine: Using the COVID-19 to influenza ratio to estimate early pandemic spread in Wuhan, China and Seattle, US

11 August 2020

Science: Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

07 August 2020

Journal of Clinical Pathology: COVID-19 salivary signature: diagnostic and research opportunities

05 August 2020

Clinical Infectious Diseases: Unique SARS-CoV-2 clusters causing a large COVID-19 outbreak in Hong Kong

04 August 2020

Cell Research: SARS-CoV-2 infects human neural progenitor cells and brain organoids
Link to press release

28 July 2020

International Journal of Molecular Sciences: A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19

28 July 2020

Nature Microbiology: Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

22 July 2020

Journal of Medical Internet Research: Impact of National Containment Measures on Decelerating the Increase in Daily New Cases of COVID-19 in 54 Countries and 4 Epicenters of the Pandemic: Comparative Observational Study

BMJ Open: Artificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial

21 July 2020

Science: Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions
Link to press release

Journal of Neuroimmune Pharmacology: The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

15 July 2020

Clinical Infectious Diseases: SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters

13 July 2020

ACS Applied Materials & Interfaces: A Surface Coating that Rapidly Inactivates SARS-CoV-2

08 July 2020

Journal of Hospital Infection: Factors affecting stability and infectivity of SARS-CoV-2

03 July 2020

Emerging Microbes & Infections: High neutralizing antibody titer in intensive care unit patients with COVID-19

02 July 2020

Clinical Infectious Diseases: Importance of face masks for COVID-19 – a call for effective public education

01 July 2020

Cell Research: Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients

24 June 2020

Influenza and Other Respiratory Viruses: SARS‐CoV‐2 environmental contamination associated with persistently infected COVID‐19 patients 

23 June 2020

Journal of Clinical Virology: Evaluation of simple nucleic acid extraction methods for the detection of SARS-CoV-2 in nasopharyngeal and saliva specimens during global shortage of extraction kits 

21 June 2020

Journal of Infectious Diseases: Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation 

20 June 2020

Emerging Microbes & Infections: SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists 

18 June 2020

Clinical Infectious Diseases: Reconstruction of Transmission Pairs for Novel Coronavirus Disease 2019 (COVID-19) in Mainland China: Estimation of Super-spreading Events, Serial Interval, and Hazard of Infection 

12 June 2020

The Lancet Infectious Diseases: SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series 

11 June 2020

Hong Kong Medical Journal: Responding to COVID-19 in Hong Kong 

10 June 2020

Viruses: Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19) 

08 June 2020

Infection Control & Hospital Epidemiology: Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19) 

PLOS Pathogens: Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus 

07 June 2020

Open Forum Infectious Diseases: Early Morning Versus Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-wide Screening 

05 June 2020

Open Forum Infectious Diseases: Olfactory dysfunction in COVID-19 patients: observational cohort study and systematic review

Journal of Medical Virology: Identification of nsp1 gene as the target of SARS‐CoV‐2 real‐time RT‐PCR using nanopore whole genome sequencing

04 June 2020

Psycho-Oncology: Psychological distress during the 2019 Coronavirus Disease (COVID ‐19) pandemic among cancer survivors and healthy controls

03 June 2020

The Lancet Microbe: Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study

02 June 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control Releases Superspreading and Latest Epidemiologic Update of COVID-19
Link to press release

Emerging Infectious Diseases: Effect of Nonpharmaceutical Interventions on Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, South Korea, 2020

01 June 2020

Pediatric Pulmonology: Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS

Journal of Clinical Microbiology: Clinical performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 detection in nasopharyngeal specimens of COVID-19 patients in Hong Kong

30 May 2020

Clinical Infectious Diseases: Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19)

29 May 2020

Graefe's Archive for Clinical and Experimental Ophthalmology: Tele-ophthalmology amid COVID-19 pandemic—Hong Kong experience

28 May 2020

Pharmacological Research: Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Gastroenterology: Association between famotidine use and COVID-19 severity in Hong Kong: a territory-wide study

27 May 2020

Journal of Clinical Virology: Evaluation of the commercially available LightMix® Modular E-gene kit using clinical and proficiency testing specimens for SARS-CoV-2 detection

Emerging Microbes & Infections: Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2

24 May 2020

American Journal of Infection Control: Absence of nosocomial transmission of coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in the pre-pandemic phase in Hong Kong

21 May 2020

JAMA Network Open: Estimating Coronavirus Disease 2019 Infection Risk in Health Care Workers

17 May 2020

Cell Reports: Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

15 May 2020

Journal of Hospital Infection: Is it possible to achieve 100 percent hand hygiene compliance during the COVID-19 pandemic?

Clinical Infectious Diseases: Case fatality risk of the first pandemic wave of novel coronavirus disease 2019 (COVID-19) in China

14 May 2020

Nature: Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
Link to press release

Nature: Infection of dogs with SARS-CoV-2

The Lancet: Global coordination on cross-border travel and trade measures crucial to COVID-19 response

Virus Evolution: Multivariate analyses of codon usage of SARS-CoV-2 and other betacoronaviruses

Cell: Structural and Functional Basis of SARS-CoV-2 Entryby Using Human ACE2

13 May 2020

Nature Medicine: Infection of bat and human intestinal organoids by SARS-CoV-2 

12 May 2020

JMIR Mental Health: Mental Health, Risk Factors, and Social Media Use During the COVID-19 Epidemic and Cordon Sanitaire Among the Community and Health Professionals in Wuhan, China: Cross-Sectional Survey

08 May 2020

The Lancet: Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

07 May 2020

The Lancet Respiratory Medicine: Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures
Link to press release

06 May 2020

Nature Reviews Physics: Modelling COVID-19

04 May 2020

The BMJ: Monitoring respiratory infections in covid-19 epidemics

Eye: Diabetic retinopathy screening during the coronavirus disease 2019 pandemic

Emerging Microbes & Infections: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

01 May 2020

Journal of Cataract and Refractive Surgery: The case for continuing elective cataract surgery during the COVID-19 pandemic

25 April 2020

Chinese Journal of Biotechnology (生物工程学报): Diagnosis, Treatment, Control and Prevention of SARS-CoV-2 and Coronavirus Disease 2019: Back to the Future (2019新型冠状病毒及其诊疗与防控:回顾与展望)

23 April 2020

Medical Education: Ophthalmic clinical skills teaching in the time of COVID‐19: A crisis and opportunity

Journal of Infection: The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2

Eurosurveillance: Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020

22 April 2020

Clinical Infectious Diseases: A case series of children with Coronavirus Disease 2019: what have we learned?

21 April 2020

The Lancet Public Health: Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study

Eye: Maintenance of ophthalmic specialist out-patient service during the COVID-19 outbreak: The University of Hong Kong experience

17 April 2020

The Lancet Public Health: Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study
Link to press release

15 April 2020

HKUMed: HKUMed research shows that stroke patients are presenting to hospitals one hour later during COVID-19, potentially jeopardising the patients’ eligibility for treatments and affecting the outcome
Link to press release

Nature Medicine: Temporal dynamics in viral shedding and transmissibility of COVID-19 

The New England Journal of Medicine: From a Sprint to a Marathon in Hong Kong

09 April 2020

Clinical Infectious Diseases: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

08 April 2020

The Lancet: First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment

International Journal of Molecular Sciences: Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens

Journal of Hospital Infection: Disinfection of N95 respirators by ionized hydrogen peroxide during pandemic coronavirus disease 2019 (COVID-19) due to SARS-CoV-2

03 April 2020

Disaster Medicine and Public Health Preparedness: Limited early warnings and public attention to COVID-19 in China, January-February, 2020: a longitudinal cohort of randomly sampled Weibo users

Gastroenterology: Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

Nature Medicine: Respiratory virus shedding in exhaled breath and efficacy of face masks

The BMJ: Covid-19: how a virus is turning the world upside down

Antiviral Research: Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

02 April 2020

The Lancet Microbe: Stability of SARS-CoV-2 in different environmental conditions

31 March 2020

International Journal of Epidemiology: COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective

26 March 2020

Nature: Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

Clinical Infectious Diseases: Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility 

The New England Journal of Medicine: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

23 March 2020

The Lancet Infectious Diseases: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

20 March 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time situation report by the instantaneous effective reproductive number (Rt) of COVID-19
Link to presentation here

The Lancet Respiratory Medicine: Rational use of face masks in the COVID-19 pandemic

JAMA Otolaryngology – Head & Neck Surgery: Practical Aspects of Otolaryngologic Clinical Services During the 2019 Novel Coronavirus Epidemic: An Experience in Hong Kong

19 March 2020

The Lancet: Viral dynamics in mild and severe cases of COVID-19

Nature Medicine: Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

Emerging Infectious Diseases: Serial Interval of COVID-19 among Publicly Reported Confirmed Cases

16 March 2020

Cell & Bioscience: SARS-CoV-2 and COVID-19: The most important research questions

14 March 2020

Emerging Microbes & Infections: A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses

12 March 2020

The New England Journal of Medicine: Detection of Covid-19 in Children in Early January 2020 in Wuhan, China

Microbiology Resource Announcements: Complete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in Nepal

06 March 2020

The Lancet: COVID-19: the gendered impacts of the outbreak 

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases case fatality risk of COVID-19
Link to presentation

The Lancet: Are high-performing health systems resilient against the COVID-19 epidemic?

The Lancet: SARS-CoV-2 is an appropriate name for the new coronavirus

05 March 2020

Infection Control & Hospital Epidemiology: Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong

04 March 2020

Journal of Clinical Microbiology: Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens

02 March 2020

Nature Microbiology: The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

28 February 2020

The New England Journal of MedicineClinical Characteristics of Coronavirus Disease 2019 in China

27 February 2020

Nature Medicine: Emergence of a novel human coronavirus threatening human health

British Journal of Anaesthesia: Outbreak of a new coronavirus: what anaesthetists should know

26 February 2020

Clinical Chemistry: The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception  

24 February 2020

The Lancet Infectious Diseases: COVID-19 pneumonia: what has CT taught us?  

The Lancet Infectious Diseases: Viral load of SARS-CoV-2 in clinical samples

21 February 2020

The Journal of the American Medical Association: Presumed Asymptomatic Carrier Transmission of COVID-19

20 February 2020

HKUMed: Pseudo-colour scanning electron micrograph of SARS-CoV-2 grown in culture from a patient isolate. After 24 hours in culture there are large numbers of orange viral particles on the surface of the cell (blue). Image courtesy of LKS Faculty of Medicine,  Department of Electrical and Electronic Engineering (K.Tsia, K.Lee and Q.Lai), and Electron Microscopy Unit, The University of Hong Kong 
Link to high-resolution image

The Lancet Digital Health: Crowdsourcing data to mitigate epidemics 

19 February 2020

The New England Journal of Medicine: SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients - 

13 February 2020

Emerging Infectious Diseases: Risk for Transportation of 2019 Novel Coronavirus Disease from Wuhan to Other Cities in China 

Eurosurveillance: Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak

12 February 2020

Clinical Infectious Diseases: Consistent Detection of 2019 Novel Coronavirus in Saliva

10 February 2020

The Lancet Infectious Diseases: The first 2019 novel coronavirus case in Nepal

06 February 2020

Emerging Infectious Diseases: Nonpharmaceutical Measures for Pandemic Influenza in Nonhealthcare Settings — Social Distancing Measures 

HKUMed: Thin-section electron micrographs of the 2019 novel coronavirus grown in cells at The University of Hong Kong. The image shows part of a virus infected cell grown in culture with multiple virus particles being released from the cell surface. Each infected cell produces thousands of new infectious virus particles which can go on to infect new cells. Image credit: John Nicholls, Leo Poon and Malik Peiris, The University of Hong Kong 
Link to high-resolution image

05 February 2020

HKUMed: Short Video of the new Novel Coronavirus Growing in Culture

03 February 2020

The BMJ Opinion: We need new forms of governance to better manage our response to pandemics -

31 January 2020

Clinical Chemistry: Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia - 

The BMJ: Response to the emerging novel coronavirus outbreak 

The Lancet: Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

29 January 2020

The New England Journal of Medicine: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

27 January 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time nowcast on the likely extent of the Wuhan coronavirus outbreak, and forecasts domestic and international spread – UPDATE
Link to presentation here

24 January 2020

The Lancet: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

23 January 2020

Eurosurveillance: Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020

22 January 2020

Eurosurveillance: Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR 

Eurosurveillance: Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020

21 January 2020

HKUMed: Statistical Tool for Predictive Analytics to Provide Real Time Estimates 

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time nowcast on the likely extent of the Wuhan coronavirus outbreak, domestic and international spread with the forecast for chunyun
Link to presentation here

18 January 2020

Journal of Hospital Infection: Preparedness and proactive infection control measures against the emerging novel coronavirus in China

16 January 2020

WHO: Detection of 2019 novel coronavirus (2019-nCoV) in suspected human cases by RT-PCR