HKUMed on COVID-19

Our Research


17 May 2020

Cell Reports: Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30702-6

14 May 2020

Nature: Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
https://www.nature.com/articles/s41586-020-2342-5
Link to press release

Nature: Infection of dogs with SARS-CoV-2
https://www.nature.com/articles/s41586-020-2334-5

The Lancet: Global coordination on cross-border travel and trade measures crucial to COVID-19 response
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31032-1/fulltext

Virus Evolution: Multivariate analyses of codon usage of SARS-CoV-2 and other betacoronaviruses
https://academic.oup.com/ve/article/6/1/veaa032/5837024

13 May 2020

Nature Medicine: Infection of bat and human intestinal organoids by SARS-CoV-2
https://www.nature.com/articles/s41591-020-0912-6 

12 May 2020

JMIR Mental Health: Mental Health, Risk Factors, and Social Media Use During the COVID-19 Epidemic and Cordon Sanitaire Among the Community and Health Professionals in Wuhan, China: Cross-Sectional Survey
https://mental.jmir.org/2020/5/e19009/

08 May 2020

The Lancet: Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext

07 May 2020

The Lancet Respiratory Medicine: Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30193-4/fulltext
Link to press release

06 May 2020

Nature Reviews Physics: Modelling COVID-19
https://www.nature.com/articles/s42254-020-0178-4

04 May 2020

The BMJ: Monitoring respiratory infections in covid-19 epidemics
https://www.bmj.com/content/369/bmj.m1628

Eye: Diabetic retinopathy screening during the coronavirus disease 2019 pandemic
https://www.nature.com/articles/s41433-020-0928-7

Emerging Microbes & Infections: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1756700

01 May 2020

Journal of Cataract and Refractive Surgery: The case for continuing elective cataract surgery during the COVID-19 pandemic
https://journals.lww.com/jcrs/Citation/9000/The_case_for_continuing_elective_cataract_surgery.99867.aspx

23 April 2020

Medical Education: Ophthalmic clinical skills teaching in the time of COVID‐19: A crisis and opportunity
https://onlinelibrary.wiley.com/doi/abs/10.1111/medu.14189

Journal of Infection: The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2
https://www.journalofinfection.com/article/S0163-4453(20)30235-8/fulltext

Eurosurveillance: Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.16.2000421

22 April 2020

Clinical Infectious Diseases: A case series of children with Coronavirus Disease 2019: what have we learned?
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa469/5823615

21 April 2020

The Lancet Public Health: Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(20)30089-X/fulltext

Eye: Maintenance of ophthalmic specialist out-patient service during the COVID-19 outbreak: The University of Hong Kong experience
https://www.nature.com/articles/s41433-020-0887-z

17 April 2020

The Lancet Public Health: Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(20)30090-6/fulltext#
Link to press release

15 April 2020

HKUMed: HKUMed research shows that stroke patients are presenting to hospitals one hour later during COVID-19, potentially jeopardising the patients’ eligibility for treatments and affecting the outcome
Link to press release

Nature Medicine: Temporal dynamics in viral shedding and transmissibility of COVID-19
https://www.nature.com/articles/s41591-020-0869-5 

The New England Journal of Medicine: From a Sprint to a Marathon in Hong Kong
https://www.nejm.org/doi/full/10.1056/NEJMc2009790

09 April 2020

Clinical Infectious Diseases: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa410/5818134

08 April 2020

The Lancet: First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30746-7/fulltext

International Journal of Molecular Sciences: Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens
https://www.mdpi.com/1422-0067/21/7/2574

03 April 2020

Disaster Medicine and Public Health Preparedness: Limited early warnings and public attention to COVID-19 in China, January-February, 2020: a longitudinal cohort of randomly sampled Weibo users
https://www.cambridge.org/core/journals/disaster-medicine-and-public-health-preparedness/article/limited-early-warnings-and-public-attention-to-covid19-in-china-januaryfebruary-2020-a-longitudinal-cohort-of-randomly-sampled-weibo-users/366C1FCCC82250274C1C1B64BAC9CECB#

Gastroenterology: Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis
https://www.gastrojournal.org/article/S0016-5085(20)30448-0/fulltext

Nature Medicine: Respiratory virus shedding in exhaled breath and efficacy of face masks
https://www.nature.com/articles/s41591-020-0843-2

The BMJ: Covid-19: how a virus is turning the world upside down
https://www.bmj.com/content/369/bmj.m1336

Antiviral Research: Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
https://www.sciencedirect.com/science/article/pii/S016635422030200X

02 April 2020

The Lancet Microbe: Stability of SARS-CoV-2 in different environmental conditions
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30003-3/fulltext

31 March 2020

International Journal of Epidemiology: COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective
https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyaa044/5813980

26 March 2020

Nature: Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins
https://www.nature.com/articles/s41586-020-2169-0

Clinical Infectious Diseases: Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa325/5811871

26 March 2020

The New England Journal of Medicine: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
https://www.nejm.org/doi/full/10.1056/NEJMoa2001316

23 March 2020

The Lancet Infectious Diseases: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30196-1/fulltext

20 March 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time situation report by the instantaneous effective reproductive number (Rt) of COVID-19
Link to presentation here

The Lancet Respiratory Medicine: Rational use of face masks in the COVID-19 pandemic
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30134-X/fulltext#

JAMA Otolaryngology – Head & Neck Surgery: Practical Aspects of Otolaryngologic Clinical Services During the 2019 Novel Coronavirus Epidemic: An Experience in Hong Kong
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2763406

19 March 2020

The Lancet: Viral dynamics in mild and severe cases of COVID-19
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30232-2/fulltext

Nature Medicine: Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China
https://www.nature.com/articles/s41591-020-0822-7

Emerging Infectious Diseases: Serial Interval of COVID-19 among Publicly Reported Confirmed Cases
https://wwwnc.cdc.gov/eid/article/26/6/20-0357_article

12 March 2020

The New England Journal of Medicine: Detection of Covid-19 in Children in Early January 2020 in Wuhan, China
https://www.nejm.org/doi/full/10.1056/NEJMc2003717

06 March 2020

The Lancet: COVID-19: the gendered impacts of the outbreak
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30526-2/fulltext 

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases case fatality risk of COVID-19
Link to presentation

The Lancet: Are high-performing health systems resilient against the COVID-19 epidemic?
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30551-1/fulltext

05 March 2020

Infection Control & Hospital Epidemiology: Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/escalating-infection-control-response-to-the-rapidly-evolving-epidemiology-of-the-coronavirus-disease-2019-covid19-due-to-sarscov2-in-hong-kong/52513ACC56587859F9C601DC747EB6EC

04 March 2020

Journal of Clinical Microbiology: Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens
https://jcm.asm.org/content/58/5/e00310-20.abstract

02 March 2020

Nature Microbiology: The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
https://www.nature.com/articles/s41564-020-0695-z

28 February 2020

The New England Journal of MedicineClinical Characteristics of Coronavirus Disease 2019 in China
https://www.nejm.org/doi/full/10.1056/NEJMoa2002032

27 February 2020

Nature Medicine: Emergence of a novel human coronavirus threatening human health
https://www.nature.com/articles/s41591-020-0796-5

British Journal of Anaesthesia: Outbreak of a new coronavirus: what anaesthetists should know
https://bjanaesthesia.org/article/S0007-0912(20)30098-2/fulltext

26 February 2020

Clinical Chemistry: The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception
https://academic.oup.com/clinchem/article/66/5/644/5802466  

24 February 2020

The Lancet Infectious Diseases: COVID-19 pneumonia: what has CT taught us?
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30134-1/fulltext#  

The Lancet Infectious Diseases: Viral load of SARS-CoV-2 in clinical samples
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30113-4/fulltext

21 February 2020

The Journal of the American Medical Association: Presumed Asymptomatic Carrier Transmission of COVID-19
https://jamanetwork.com/journals/jama/fullarticle/2762028

20 February 2020

HKUMed: Pseudo-colour scanning electron micrograph of SARS-CoV-2 grown in culture from a patient isolate. After 24 hours in culture there are large numbers of orange viral particles on the surface of the cell (blue). Image courtesy of LKS Faculty of Medicine,  Department of Electrical and Electronic Engineering (K.Tsia, K.Lee and Q.Lai), and Electron Microscopy Unit, The University of Hong Kong 
Link to high-resolution image

The Lancet Digital Health: Crowdsourcing data to mitigate epidemics
https://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30055-8/fulltext 

19 February 2020

The New England Journal of Medicine: SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients - 
https://www.nejm.org/doi/full/10.1056/NEJMc2001737 

13 February 2020

Emerging Infectious Diseases: Risk for Transportation of 2019 Novel Coronavirus Disease from Wuhan to Other Cities in China
https://wwwnc.cdc.gov/eid/article/26/5/20-0146_article 

Eurosurveillance: Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak  
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.6.2000110

12 February 2020

Clinical Infectious Diseases: Consistent Detection of 2019 Novel Coronavirus in Saliva 
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa149/5734265

10 February 2020

The Lancet Infectious Diseases: The first 2019 novel coronavirus case in Nepal 
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30067-0/fulltext#

06 February 2020

Emerging Infectious Diseases: Nonpharmaceutical Measures for Pandemic Influenza in Nonhealthcare Settings — Social Distancing Measures
https://wwwnc.cdc.gov/eid/article/26/5/19-0995_article 

HKUMed: Thin-section electron micrographs of the 2019 novel coronavirus grown in cells at The University of Hong Kong. The image shows part of a virus infected cell grown in culture with multiple virus particles being released from the cell surface. Each infected cell produces thousands of new infectious virus particles which can go on to infect new cells. Image credit: John Nicholls, Leo Poon and Malik Peiris, The University of Hong Kong 
Link to high-resolution image

05 February 2020

HKUMed: Short Video of the new Novel Coronavirus Growing in Culture
https://www.youtube.com/watch?v=aOZvf5NOFHs

03 February 2020

The BMJ Opinion: We need new forms of governance to better manage our response to pandemics - 
https://blogs.bmj.com/bmj/2020/02/03/we-need-new-forms-of-governance-to-better-manage-our-response-to-pandemics/

31 January 2020

Clinical Chemistry: Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia - 
https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvaa029/5719336 

The BMJ: Response to the emerging novel coronavirus outbreak
https://www.bmj.com/content/368/bmj.m406 

The Lancet: Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30260-9/fulltext

29 January 2020

The New England Journal of Medicine: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
https://www.nejm.org/doi/full/10.1056/NEJMoa2001316#.XjIZLaUBk_E

27 January 2020

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time nowcast on the likely extent of the Wuhan coronavirus outbreak, and forecasts domestic and international spread – UPDATE
Link to presentation here

24 January 2020

The Lancet: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster 
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30154-9/fulltext

23 January 2020

Eurosurveillance: Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020
https://www.eurosurveillance.org/docserver/fulltext/eurosurveillance/25/3/eurosurv-25-3-2.pdf?expires=1590117129&id=id&accname=guest&checksum=161156FE727C880B4DDC08691944C0BE

22 January 2020

Eurosurveillance: Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.3.2000045 

Eurosurveillance: Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.3.2000044

21 January 2020

HKUMed: Statistical Tool for Predictive Analytics to Provide Real Time Estimates
http://www3.influenza.hk/wuhan/ 

HKUMed: HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control releases real-time nowcast on the likely extent of the Wuhan coronavirus outbreak, domestic and international spread with the forecast for chunyun
Link to presentation here

18 January 2020

Journal of Hospital Infection: Preparedness and proactive infection control measures against the emerging novel coronavirus in China
https://www.journalofhospitalinfection.com/article/S0195-6701(20)30034-7/fulltext

16 January 2020

WHO: Detection of 2019 novel coronavirus (2019-nCoV) in suspected human cases by RT-PCR 
https://www.who.int/docs/default-source/coronaviruse/peiris-protocol-16-1-20.pdf?sfvrsn=af1aac73_4