Poster Presentation

LAMP1 overexpression predicts poor prognosis in diffuse large B cell lymphoma

Dr Shi Wenyu
Affiliated Hospital of Nantong University

Abstract

Lysosomal-associated membrane protein 1 (LAMP1) is a lysosomal and plasma membrane protein that contributes to tumor metastatic potential and differentiation. Here, we performed immunohistochemical staining to investigate the LAMP1 protein expression levels in 122 diffuse large B cell lymphoma (DLBCL) tumor samples and 45 reactive hyperplasia tissues. Correlations between LAMP1 expression, various clinicopathological features and patient prognosis were evaluated by univariate and multivariate analysis. We found that LAMP1 expression was higher in DLBCL tissues compared with reactive hyperplasia tissues. High LAMP1 expression was significantly associated with the international prognostic index score (p = 0.023) and lactate dehydrogenase level (p = 0.028). Moreover, LAMP1 expression (p = 0.026), serum lactate dehydrogenase level (p = 0.011) and international prognostic index score (p<0.001) were independently associated with worse overall survival. These data provide the first evidence that LAMP1 expression is associated with poor prognosis in patients with DLBCL.