Poster Presentation
Vascular factors associated with bronchopulmonary dysplasia in preterm infants
Dr Han Tongyan
The Third Hospital of Peking University
Abstract
Background and Aims
To analysis the role of vascular endothelial growth factor-A(VEGF-A), angiopoietin-1(Ang-1), angiotensin converting enzyme (ACE) in the development of BPD in preterm infants (<34w).
Methods
Data were collected from NICU in Peking University Third Hospital from Dec. 2015 to Apr. 2017. All preterm infants whose gestational age were <34 weeks or birth weight were <1500g and survived over 28 days were included in this study. The clinical data of preterm infants including gender, gestational age, birth weight, small for gestational age, maternal history were collected. Treatments for respiratory system and clinical diagnosis were recorded. Serum samples were obtained from the preterm infants at birth and on postnatal 1-day and 7-day analyzed for VEGF-A, Ang-1 and ACE in BPD and non-BPD survivors.
Results
Eighty-nine preterm infants whose gestational age <34w were enrolled into the study, of which infants with BPD accounted for 19.3%. There was shorter gestational age [(30.365±2.297) weeks VS (32.346±2.023)weeks, t=2.3.539, P=0.001] and lower birth weight [(1342.940±368.371)g VS (1769.580±357.698)g, t=4.399, P=0.000] in BPD group. More cases of BPD group had been administrated of invasive ventilation ≥7d (P=0.002) had longer duration of invasive ventilation (Z=-3.025, P=0.002), longer duration of noninvasive ventilation (Z=-4.109, P=0.000). More cases of BPD group had diagnosed hospital-acquired infectious pneumonia (P=0.007), neonatal respiratory distress syndrome(NRDS)(χ2=41.683, P=0.000), pulmonary artery hypertension (P=0.009), apnea (χ2=11.273, P=0.001), early onset sepsis (P=0.021), patent ductus arteriosus (P=0.005) and intracranial hemorrhage of two degree or above (P=0.020). A higher serum ACE [158.114 (140.340-186.568) pg/ml and 134.632 (114.024-154.211) pg/ml, Z=-2.297, P=0.022] concentration on 24-48 hours after birth was found in BPD group. In BPD group, the serum VEGF [25.011(0.000-590.435) pg/ml and 520.030 (53.268-728.640) pg/ml, Z=2.229, P=0.0026] concentration and the serum Ang-1 concentration [1.861 (0.371-2.650) *104pg/ml VS 3.252 (0.555-5.173)*104pg/ml, Z=-2.101, P=0.036] were lower than non-BPD group.
Conclusions
In the preterm infants with BPD, the VEGF-A was lower and Ang-1 and ACE were higher than those without BPD. The substantial alterations in the vascular factors may contribute to the developmental of BPD.