Keynote Lecture II

Novel strategies for neuroimaging

Huo Guo
Tsinghua University

Professor Hua Guo is a principle investigator at Center for Biomedical Imaging Research, Department of Biomedical Engineering at Tsinghua University in Beijing. He received his Ph.D. from the department of Biomedical Engineering at Duke University in 2006. He was an assistant professor in department of radiology of New York University from 2008 to 2010. Before that he once worked in Siemens as a scientist and at the University of Hong Kong as a postdoc. He has extensive research experience in MRI physics, advanced imaging method development and preclinical studies. His primary research interest focuses on two core areas in MRI. The first one is MRI physics including novel sequence design and image reconstruction, which can potentially provide high spatiotemporal resolution and multi-parametric quantitative imaging. Particularly, he is working on high resolution diffusion weighted imaging at present. The second area is the translational application of advanced MRI techniques for accurate diagnosis and disease management.

郭華，現任清華大學醫學院生物醫學工程系生物醫學影像研究中心特別研究員，長聘副教授，研究興趣包括磁共振物理，高解析度擴散成像，神經影像與臨床應用。2006年畢業於美國Duke University 生物醫學工程系。曾在Siemens 公司，香港大學和美國紐約大學進行磁共振成像物理與圖像重建方面的研究工作。在2010 年加盟清華大學前曾任美國紐約大學放射學系助理教授。現為NeuroImage, MRM，JMRI，NMR in Biomedicine, IEEE Transactions on Medical Imaging等多個國際研究期刊的審稿人。

Abstract

Diffusion weighted MR imaging can probe not only microstructural but also functional information of the tissue, thus it has tremendous potentials in clinical applications and neuroscience research. Due to technical limitations, traditional DWI uses single shot acquisition method to suppress motion artifacts, which inevitably has low spatial resolution, low signal to noise ratio and severe image distortion artifacts. Multi-shot diffusion imaging can be used to increase the spatial resolution. However, diffusion MRI is very sensitive to subject motion, including bulk head motion and pulsatile brain motion. In this report, I will first introduce our recent development in advanced diffusion imaging using mulitishot EPI, spiral and Turbo spin echo sequences. Then I will present other novel neuroimaging techniques developed in our center, including gray matter and white matter imaging, blood vessel imaging. Finally, I will show a few clinical applications by using these techniques.

磁共振彌散加權成像不僅能探測組織的微觀結構，還能探查其功能性資訊，因此在臨床應用和神經科學研究中具有巨大的應用潛力。但由於技術上的限制，傳統的 DWI 採用單次激發的方法來抑制運動偽影，因此不可避免地具有空間解析度低、信噪比低和嚴重的圖像失真偽影等缺點。多次激發的擴散成像可用於提高空間解析度。然而，擴散磁共振成像對受試者的運動異常敏感，比如不自主的大的頭部運動和血液和腦脊液波動。在本報告中，我將首先介紹我們在開發高解析度低變形彌散影像方面的技術進展，比如使用mulitishot EPI技術或螺旋掃描及快速回波成像方法等。然後，我將介紹我們的中心發展的其他的高級神經影像技術，包括灰質和白質成像，血管成像等。最後，我將報告一些這些高級技術的臨床應用。