HKUMed News (Vol 27 | Issue 2)

Research • The HKU-HA Data Collaboration Laboratory was launched early this year, which is expected to support a wide range of digital health and big data research going forward. • The Cryo-EM facility will begin operating in 2023 as a platform to develop impactful drug and clinical therapeutics discoveries. • By about 2025, the University Block at Grantham Hospital is expected to be completed, housing the Centre for Clinical Innovation and Discovery and the Institute for Cancer Care, which will provide dedicated facilities for oncology translational research, including advanced -omics and cell-based treatments. • Research impact would be further promoted through translational transdisciplinary research: the Centre of Cancer Medicine was recently established in October 2022 to enable staff from across departments and schools of HKUMed to better understand and combat cancer; HKUMed is also working with the Faculty of Engineering and the Faculty of Dentistry to set up a Research Hub for Biomedical Engineering, and with the Faculty of Social Sciences to set up an Institute of Data Analysis and Management. 研究 • 香港大學醫院管理局數據實驗室已於今年年初成立,預計將 支持廣泛的數碼健康和大數據研究。 • 低溫電子顯微設施將於2023年開始運作,成為開發重要藥物 和臨床治療的平台。 • 葛量洪醫院的大學樓預計將於2025年左右建成,當中包括臨 床創新及硏發中心與癌症綜合關護中心,為腫瘤轉化研究提 供專門的設施,包括先進的體學和細胞療法等。 • 跨學科轉化研究將進一步提升研究的影響力:癌症醫學中心 已於2022年10月成立,旨在加強港大醫學院各院系員工對 癌症的了解,從而提供更有效的治療;港大醫學院亦與工程 學院及牙醫學院合作,成立生物醫學工程研究中心,並與社 會科學學院合作成立數據分析及管理研究所。 Pursuing Major Research on Lupus Professor Lau is a co-principal investigator of the Centre for Translational Stem Cell Biology, which has received HK$284.6 million under Health@InnoHK. His work there will deepen knowledge about systemic lupus erythematosus, an autoimmune disease that affects predominantly young females and is associated with high morbidity and mortality. The first aim is to classify and categorise patients with different types of lupus and try to develop their blood cells into stem cell platforms so their immune cells can be studied in more detail. The team will also use patient stem cells to grow organoids – tiny organs – to try to understand how the patients’ immune systems are causing disease in such organs as the kidneys. And they will look at immune deficiencies to understand the role of different immune cells in defence against infection. This long-term project is expected to result in, among other things, the identification of new cellular or molecular targets that can be further investigated as possible biomarkers or therapy candidates. 關於紅斑狼瘡的重要研究 劉教授是幹細胞轉化硏究中心的聯合首席研究員,該中心 於Health@InnoHK創新平台獲得2.846億港元經費。劉教授的 工作將加深對系統性紅斑狼瘡的認識,這是一種主要影響年輕 女性、發病率和死亡率相當高的自身免疫疾病。 硏究的首要目標是將患有不同類型紅斑狼瘡的患者分類, 並嘗試將他們的血液細胞發展成幹細胞平台,以便更詳細地研 究他們的免疫細胞。團隊亦會使用患者的幹細胞來培養類器 官⸺微小器官⸺以試圖了解患者的免疫系統如何在腎臟等 器官中引起疾病。此外,團隊也將研究免疫缺陷,以了解不同 免疫細胞在防禦感染中的作用。這個長期項目預計將可鑑定新 的細胞或分子標靶作進一步研究,以成為生物標記或判斷相關 治療是否適合。 21 HKUMed News Winter 2022