EY1920 Year Book

61 60 Chu Sheung Chit Academic Strategic Analysis of Hospital Authority Using SWOT model, stakeholder analysis and PEST-analysis to show how HA can improve management Experience Economic Evaluation of Alzheimer’s Treatment • Evaluate the cost effectiveness of vitamin B compared to current Alzheimer’s treatment in slowing the progression of mild cognitive impairment • Ongoing Economic Analysis of contracting psychiatric specialist outpatient services to clinical psychologist and social workers Compared to increasing the employment of psychiatrists, contracting psychiatric SOP services for stable cases to social workers and clinical psychologists is expected to increase contestability of labour market, achieve social allocation efficiency and improve vertical equity How evidence, power and politics influence the e-cigarette ban policy of Hong Kong During the formulation of policies involving conflicts of interests, such as tobacco policies, interest groups would have strong power to utilise evidence and advocate the media and the public to pressurise the legislature and the government. London Model World Health Organisation Simulation • Representing Laos as the delegate • Raising motions and resolution papers • Being interviewed by BBC representative • Honourable Mention in WPRO Hong Kong Student Association of Neuroscience • External Vice President • Holding the first webinar in May • Holding Neurosurgery Bootcamp in CUHK • Organising Annual Conference in the coming months Life MSc Public Health MBBS Enrichment Year 2019/20 Chu Sheung Chit Full Year < IC - I nter c alate d d egree at Lo n do n Sc h oo l of H y giene an d T r op i c al Me d i c ine , U K > Neurodevelopment – The Subplate Over the past years the understanding of neuropsychiatric diseases has shifted from an imbalance of neurotransmitters to the disturbance of specific brain circuits. Characterising disease- relevant brain circuits and their cell types have therefore become critical to identify novel therapeutic interventions. Due to limited genetic tools to label and manipulate specific neuronal populations, functional activity of the subplate, a transient population of early-born cortical neurons in the neocortex, have remain largely unexplored despite evidence showing that it plays a crucial role in the cerebral cortex development. I was involved in a research aiming to characterise the function of a novel subpopulation of subplate neurons (SPN) in mouse models as well as single cell level genomics with the ultimate aim of characterising circuits involving the human subplate, which are implicated in autism, schizophrenia and many other neurodevelopmental disorders. Methodology We are utilising a transgenic mouse line, 921CT2IG for the experiments and hypothesize that projections from this subpopulation, called 921SPNs is activity-dependent. We will micro-dissect the dorsal cortex, dissociate the cells and use Fluorescence Activated Cell Sorting (FACS) to purify 921SPNs from mice at different embryonic stages. The cells will be used for RNA sequencing to profile the expression of genes involved in synaptogenesis and the extension of thalamocortical axons. Data generated from the mouse models will then be compared with the human enhancers identified previously in the same project and used for analysis of gene conservation between species. We also utilise a mix of laboratory techniques, particularly in histology and staining to visualize the migration of subplate neurons in the 921 transgenic mouse line at different embryonic stages. Preliminary Results From the preliminary data alone, the activity of the subpopulation of SPNs labelled seem to be consistent with the existing literature. The axonal extension of the subpopulation of SPNs are also clearly labelled under higher magnification when they are harvested at E15.5. Higher magnification histological examination and confocal imaging of the neurons will be done to closely examine the morphological properties of the labelled cells and processes. In the future, using genetic tools such as transcriptomic analysis such as promoters and enhancers to label subpopulations of the cerebral cortex may help to elucidate the role of the SP in these neuropsychiatric diseases, and eventually finding therapeutic intervention Besides research, I also joint the Yale Taekwondo team! Back in clinical years, I rarely exercised and figured that I should make a change to the sedentary lifestyle so I decided to pick up a new sport at Yale. Taekwondo requires good cardio fitness, balance and flexibility and I had a good time in the team! In January 2020, I joined the Inaugural Yale Institute for Global Health Case Competition. Our team comprising of students from different disciplines presented our solution to open defaecation in India and was placed first. In March, I led the team as the team captain, and we had the honour to represent Yale in the Emory International Global Health Case Competition and competed against universities from around the world on the topic of of the measles epidemic. Yale Institute for Global Health Case Competition 2020 Besides academic work, I took time during the weekends and winter break to go to different places in North America such as New York City, Boston, and Toronto. Spending a white Christmas in Quebec City was definitely a highlight and great end to 2019! | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | MBBS Enrichment Year 2019/20 Chui Jacklyn Hoi Ying Full Year < RA - Spatiotemporal molecular profiling of the subplate layer, a developmental structure implicated in Autism and Schizophrenia at Yale University, US > | Chui Jacklyn Hoi Ying