EY1920 Year Book

49 48 MBBS Enrichment Year 2019/20 Cheung Wai Lok Full Year < IC - Min o r in Kine s i o l o g y at HK U, H o ng K o ng > Cheung Wai Lok Research Attachment at Department of Diagnostic Radiology, HKU Cardiac MR Intraventricular 4D Flow to differentiate HFpEF from non-HFpEF patients Objectives: • Evaluate difference in terms of intraventricular blood flow between patients with heart failure with preserved ejection fraction (HFpEF) and non-HFpEF patients by novo 4D Flow technology in cardiac magnetic resonance imaging (CMR) • Explore possibility of the use of 4D Flow and/or cardiac MRI in diagnosis of HFpEF Methodology: • Prospective case control study • Participants took blood tests (NT-proBNP and complete blood picture), echocardiogram, cardiac magnetic resonance (CMR) assessment (including 4D Flow imaging) within 24 hours. • HFpEF was diagnosed based on the European Society of Cardiology (ESC) criteria (1. Symptoms and signs of heart failure; 2. Elevated NT- ProBNP; 3. Either one of a) left ventricular hypertrophy, b) left atrial dilatation or c) heart failure admission within 9 months). • Four parameters regarding left intraventricular flow are direct flow, delayed ejection, retained inflow and residual volume ; pulse wave velocity was determined by CMR 4D Flow and T1 weighted imaging parameters were also assessed by CMR • Statistics were performed by SPSS IBM statistics (version 26). Mann Whitney U test, independent samples T-test, chi-squared test were performed for finding out statistically significant difference between HFpEF and non-HFpEF patients regarding the measured parameters; Pearson’s correlation was performed for detecting correlation between different CMR parameters. Result: • Demographics: HFpEF patients were older (p=0.002) than non-HFpEF patients and more likely to have hypertension (p=0.006). • CMR 4D Flow parameters : HFpEF patients (compared to non-HFpEF patients) had significantly lower direct flow (p=0.015) , higher delayed ejection (p=0.044) and higher retained inflow (p=0.044). • T1 weighted imaging parameters: HFpEF patients were assessed to have higher left atrium volume indexed (LAV indexed) (p=0.001) and native T1 myocardium (p=0.013). • Correlation: Direct flow significantly correlated with LVEF (p<0.01), and correlated negatively with LVESVi (p<0.01), LVEDVi and LAV indexed (p<0.05) . Delayed ejection/ retained inflow inversely correlated with LVEF (p<0.01), and positively correlated with LVESVi (p<0.01), LVEDVi and LAV indexed (p<0.05). Conclusion: • Direct flow, delayed ejection and retained inflow assessed by CMR 4D Flow had potential to become indicators for HFpEF diagnosis. My Life at King’s College London - Courses Greek Philosophy Learning ancient Greek Philosophy is a difficult task. Reading passages written by Plato and Aristotle, with claims made by Socrates and pre-Socratics, I’ve gained new perspectives about metaphysics and life of philosophy. Source: Lecture from Professor Katharine O’Reilly (KCL) Epistemology Seldom is known about this topic among student who didn’t study philosophy. After studying biochemistry, anatomy and pharmacology, do we really “know” the things that we learn? The journey to knowledge and its challenges are pondered in Epistemology lessons. Publisher: Routledge, 2013 Introduction to Stem Cells Being the fascinating new thing in the medical field, stem cells study and application captured my attention. Difference sources of stem cells and the spectrum of use are explained in the course, casting new light onto their future use in medical practice. Source: National Geographic; Lecture from Dr. Dusko Ilic (KCL) MBBS Enrichment Year 2019/20 Ching On Hang Samuel Sem 1 < IC - HKUWW Exchange Programme at King ' s College London, UK >; Sem 2 < R A - Cardiac MR Intraventricular 4D F low to di ff erentiate H F pE F f rom non-H F pE F patients at D epartment o f D iagnostic R adiolog y , HKU, Hong Kong > Source: O’Shea et al., Science (2010); Lecture from Dr Faruk Ramadani (KCL) The Immune System in Health and Disease The course helps me revise knowledge about immunology, and in-depth details of molecules and immune cells make the course valuable to a preclinical medical student by facilitating the formation of a solid foundation of medical knowledge. Ching On Hang Samuel